The present review focuses on the concept that cellular and humoral immunity to the
phylogenetically highly conserved antigen heat shock protein 60 (HSP60) is the initiating …

Owing to the common coincidence of osteoporosis and vascular disease, pathophysiological
links between both disorders have long been sought. The osteoprotegerin (OPG)/receptor …

Background Arterial stiffening is central to the vascular ageing process and a powerful predictor
and cause of diverse vascular pathologies and mortality. We investigated age and sex …

Background Whether thrombectomy alone is equally as effective as intravenous alteplase
plus thrombectomy remains controversial. We aimed to determine whether thrombectomy …

The QT interval, an electrocardiographic measure reflecting myocardial repolarization, is a
heritable trait. QT prolongation is a risk factor for ventricular arrhythmias and sudden cardiac …

… Bamford J, Sandercock P, Dennis M, Burn J, Warlow C. A prospective study of acute …
Knoflach designed and conceptualized the study, interpreted the data, and drafted the …

Objective: To estimate rates, predictors, and prognostic importance of recanalization in an
unselected series of patients with stroke treated with IV thrombolysis. Methods: We performed …

Background— Necropsy studies suggest that atherosclerosis begins in childhood, but in
vivo confirmation of this concept is sparse and limited to selected population samples. …

Hepatic insulin resistance is a driving force in the pathogenesis of type 2 diabetes mellitus (T2DM)
and is tightly coupled with excessive storage of fat and the ensuing inflammation …

Objectives— Although cadmium (Cd) is an important and common environmental pollutant
and has been linked to cardiovascular diseases, little is known about its effects in initial …