MicroRNA-183 upregulates HIF-1α by targeting isocitrate dehydrogenase 2 (IDH2) in glioma cells

…, M Nishihara, K Mizukawa, M Kohta… - Journal of neuro …, 2013 - Springer
MicroRNAs (miRs) are small, non-coding RNAs that regulate gene expression and contribute
to cell proliferation, differentiation and metabolism. Our previous study revealed the …

Glioma cells require one-carbon metabolism to survive glutamine starvation

…, Y Fujita, M Hashiguchi, T Nakai, M Kohta… - Acta neuropathologica …, 2021 - Springer
Cancer cells optimize nutrient utilization to supply energetic and biosynthetic pathways.
This metabolic process also includes redox maintenance and epigenetic regulation through …

Inhibition of TGF-β1 promotes functional recovery after spinal cord injury

M Kohta, E Kohmura, T Yamashita - Neuroscience research, 2009 - Elsevier
Trauma to the spinal cord initiates a series of cellular and biochemical processes that
damage both neurons and glia. TGF-β and its receptors are expressed around the injury site …

Metabolic changes and anti-tumor effects of a ketogenic diet combined with anti-angiogenic therapy in a glioblastoma mouse model

…, S Nakamizo, M Hashiguchi, Y Fujita, M Kohta… - Scientific reports, 2021 - nature.com
The ketogenic diet (KD) is a high fat and low carbohydrate diet that produces ketone bodies
through imitation of starvation. The combination of KD and Bevacizumab (Bev), a VEGF …

Endoscopic endonasal translacerum approach to the inferior petrous apex

M Taniguchi, N Akutsu, K Mizukawa, M Kohta… - Journal of …, 2016 - thejns.org
OBJECT The surgical approach to lesions involving the inferior petrous apex (IPA) is still
challenging. The purpose of this study is to demonstrate the anatomical features of the IPA and …

Multi‐marker algorithms based on CXCL13, IL‐10, sIL‐2 receptor, and β2‐microglobulin in cerebrospinal fluid to diagnose CNS lymphoma

…, M Nishihara, Y Fujita, K Sekiguchi, M Kohta… - Cancer …, 2020 - Wiley Online Library
… MTX (3-6 g/m 2 ) was administered as an intravenous infusion over 4 hours. MTX-based
chemotherapy was administered for 1-4 cycles in each patient. In whole brain irradiation, both …

Myo-inositol concentration in MR spectroscopy for differentiating high grade glioma from primary central nervous system lymphoma

…, K Kyotani, N Sato, M Maeyama, M Kohta… - Journal of neuro …, 2018 - Springer
It is sometimes difficult to distinguish gliomas from other tumors on routine imaging. In this
study, we assessed whether 3-T magnetic resonance spectroscopy (MRS) with LCModel …

Combined IDH1 mutation and MGMT methylation status on long-term survival of patients with cerebral low-grade glioma

…, K Takata, NS Sulaiman, M Nishihara, M Kohta… - Clinical neurology and …, 2015 - Elsevier
… Serial sections were deparaffinized, immersed in methanol containing 3% hydrogen peroxide,
and heated in 0.01 M citrate buffer (pH 6.0) for 15 min by autoclaving (121 C, 2 atm). The …

A novel Rac1-GSPT1 signaling pathway controls astrogliosis following central nervous system injury

T Ishii, T Ueyama, M Shigyo, M Kohta, T Kondoh… - Journal of Biological …, 2017 - ASBMB
… The lower right panel shows the cell cycle time from the S to M phase (control: n = 15,
Rac1-KD: n = 16; *, p = 0.0292). C, from 48 to 96 h after transfection (pSUPER(gfp) (sh-cont) or …

In vitro parallel evaluation of antibacterial activity and cytotoxicity of commercially available silver-containing wound dressings

S Yunoki, M Kohta, Y Ohyabu… - Chronic Wound Care …, 2015 - Taylor & Francis
Purpose: This study evaluated the in vitro antibacterial activity and cytotoxicity of various
commercially available silver-containing dressings (Ag dressing). Methods: Biohesive Ag (…