The origin of organismal complexity is generally thought to be tightly coupled to the evolution
of new gene functions arising subsequent to gene duplication. Under the classical model …

Understanding the mechanisms of evolution requires information on the rate of appearance
of new mutations and their effects at the molecular and phenotypic levels. Although …

How is history produced? How do individuals write--or rewrite--their parts while engaged in
the production of history? Michael Lynch and David Bogen take the example of the Iran-…

Gene duplication has generally been viewed as a necessary source of material for the
origin of evolutionary novelties, but it is unclear how often gene duplicates arise and how …

… The study of Families G, N, and M, and hundreds of similar families helped to define the …
These investigators genotyped these variants in 675 individuals from the Dutch Lynch Syndrome …

IN RECENT decades it has become increasingly apparent that violence affects a significant
proportion of families in the United States (BUreau of Justice Statistics 1983). Violence, in fact…

Philosophers, historians, and sociologists of science have grown interested in the daily
practices of scientists. Recent studies have drawn linkages between scientific innovations and …

We describe the draft genome of the microcrustacean Daphnia pulex, which is only 200
megabases and contains at least 30,907 genes. The high gene count is a consequence of an …

Complete genomic sequences from diverse phylogenetic lineages reveal notable increases
in genome complexity from prokaryotes to multicellular eukaryotes. The changes include …

It has often been argued that gene-duplication events are most commonly followed by a
mutational event that silences one member of the pair, while on rare occasions both members of …