Cell growth and proliferation are tightly linked to nutrient availability. The mechanistic target
of rapamycin complex 1 (mTORC1) integrates the presence of growth factors, energy levels, …

Interleukin 1β (IL-1β) is a potent proinflammatory factor during viral infection. Its production
is tightly controlled by transcription of Il1b dependent on the transcription factor NF-κB and …

Corticosteroids have been shown to exert beneficial effects in the treatment of acute myocardial
infarction, but the precise mechanisms underlying their protective effects are unknown. …

… TraddÀ/À mice were generated and provided by M. Pasparakis. Mouse embryonic fibroblasts
… M.CM is a recipient of a fellowship from European Molecular Biology Organization (EMBO). …

Little is known about the regulation of nonapoptotic cell death. Using massive insertional
mutagenesis of haploid KBM7 cells we identified nine genes involved in small-molecule-…

… We thank M. Eckert for critical reading of the paper. JT is supported by grants of the Swiss
National Science Foundation and the European Union grants Hermione and Apotrain…

We investigated the involvement of mitogen-activated protein kinases (MAPKs) in the maturation
of CD83− dendritic cells (DC) derived from human blood monocytes. Maturating agents …

Background and purpose: The major drug‐metabolizing enzymes for the oxidation of
oxycodone are CYP2D6 and CYP3A. A high interindividual variability in the activity of these …

Necroptosis is a form of regulated necrotic cell death mediated by receptor-interacting serine/threonine-protein
kinase 1 (RIPK1) and RIPK3. Necroptotic cell death contributes to the …

Toll-like receptors (TLRs) have a crucial role in the recognition of pathogens and initiation of
immune responses 1 , 2 – 3 . Here we show that a previously uncharacterized protein …