The tumor microenvironment, including cancer-associated fibroblasts (CAF), has developed
as an important target for understanding tumor progression, clinical prognosis and treatment …

… The median improvement was 97 m (IQR 0–280 m) in the 6 min walk test and 9 (IQR –2
to 25) points in the MLHF questionnaire regarding quality of life. The improvements were …

… The authors Seifert M, Schau T, Schoepp M, Neuss M and Arya A have no conflicts of
interest. The author Butter C has received Speaker's honoraria and consultancy fee from Abbott …

BACKGROUND: Spinal muscular atrophy is a progressive neurodegenerative disorder that
can be treated with intrathecal antisense oligonucleotide therapy (nusinersen). However, …

Purpose Adults with Turner syndrome (TS) have an increased predisposition to ischemic
heart disease. The quantitative relationship between coronary atherosclerosis and TS has yet …

Current treatments for depression are less than optimal in terms of onset of action, response
and remission rates, and side-effect profiles. Glutamate is the major excitatory …

Anxiety and stress disorders are the most commonly occurring of all mental illnesses, and
current treatments are less than satisfactory. So, the discovery of novel approaches to treat …

Rationale Data from both preclinical and clinical studies have provided proof of concept that
modulation of limbic and forebrain glutamate, via mGlu2/3 receptor agonists, might provide …

Purple bacteria have thus far been considered to operate light-driven cyclic electron transfer
chains containing ubiquinone (UQ) as liposoluble electron and proton carrier. We show that …

Aims: The implantation of MitraClip (MC) is a new treatment modality for severe mitral
regurgitation (MR) in patients who are inoperable or at high conventional operative risk. This study …