The A 1 , A 2A , A 2B and A 3 G-protein-coupled cell surface adenosine receptors (ARs) are
found to be upregulated in various tumor cells. Activation of the receptors by specific ligands, …

… We observed that the distribution of TAMs in GBM is very heterogeneous and the average
number of these cells is between 20 and 30 % (M. Synowitz and R. Glass, unpublished data). …

Diffuse infiltration of glioma cells into normal brain tissue is considered to be a main reason
for the unfavorable outcomes of patients with malignant gliomas. Invasion of glioma cells into …

Malignant glioma belong to the most aggressive neoplasms in humans with no successful
treatment available. Patients suffering from glioblastoma multiforme (GBM), the highest-grade …

Gliomas represent the most frequent type of human brain tumor, and their strong invasiveness
is a significant clinical problem. Microglia, the immunocompetent cells of the brain, …

Neural precursor cells contribute to adult neurogenesis and to limited attempts of brain repair
after injury. Here we report that in a murine experimental glioblastoma model, endogenous …

… µm of atorvastatin for 4 days in most of the cases, we chose a lower concentration (100 nm) …
to the culture medium at a concentration of 50 µm for 1 h and then removed. NMDA, kainate …

Primary astrocytomas of grade 3 or 4 according to the classification system of the World
Health Organization (high-grade astrocytomas or HGAs) are preponderant among adults and …

Sorting protein-related receptor with A-type repeats (SORLA) is a major risk factor in cellular
processes leading to Alzheimer's disease (AD). It acts as sorting receptor for the amyloid …

Background Accumulation and infiltration of microglia/brain macrophages around and into
glioma tissue promote tumor invasion and expansion. One tumor-promoting mechanism of …