Objective Friedreich ataxia (FRDA) is an inherited neurological disease defined by progressive
movement incoordination. We undertook a comprehensive characterization of the spatial …

… ± 104.37 m) compared to the predicted distance for matched healthy controls (593 ±57 m)
[41]. … in ambulant SPG5 patients (64.80 m), the mildest in SPG4 (412.20 m). However, a wide …

Introduction The Hereditary Spastic Paraplegia (HSP) is a heterogeneous group of
neurodegenerative disorders characterized by progressive spasticity and lower limbs (LL) weakness. …

… Marinela Vavla … The median BMI in this cohort was 25.9 kg/m 2 (range: 16.6–52.8 kg/m
2 ). Abnormal BMI was observed in 62.6% (Fig. 2). … Marinela Vavla …

Friedreich's ataxia (FRDA) is a rare hereditary neurodegenerative disorder caused by a GAA
repeat expansion in the FXN gene. There is still no cure or quantitative biomarkers reliaby …

BACKGROUND AND PURPOSE: The hereditary spastic paraplegias are a group of genetically
heterogeneous neurodegenerative disorders, characterized by progressive spasticity …

Friedreich's ataxia (FRDA) is an inherited neurodegenerative movement disorder with early
onset, widespread cerebral and cerebellar pathology, and no cure still available. Functional …

Friedreich’s ataxia (FRDA) is the most frequent among the autosomal recessive ataxias,
caused by an insufficient production of the mitochondrial protein frataxin and characterized by a …

The identification of efficient markers of disease progression and response to possibly effective
treatments is a key priority for slowly progressive, rare and neurodegenerative diseases, …

Introduction The relevance of rehabilitation in progressive neurological disorders, such as
Friedreich’s Ataxia (FRDA), has yet to be convincingly proven. FRDA is characterized by ataxia…