Preclinical models for musculoskeletal disorders are critical for understanding the pathogenesis
of bone and joint disorders in humans and the development of effective therapies. The …

The blood–brain barrier (BBB), a critical guardian of communication between the periphery
and the brain, is frequently compromised in neurological diseases such as multiple sclerosis (…

MRI offers high spatial resolution with excellent tissue penetration but it has limited sensitivity
and the commonly administered contrast agents lack specificity. In this study, two sets of …

Research ethics committee approval was obtained for this study, and written informed
consent was obtained from all participants. The purpose was to prospectively evaluate the …

Objectives Identification of those patients with high-risk asymptomatic carotid plaques remains
an elusive but essential step in stroke prevention. Inflammation is a key process in plaque …

Background Brain change can occur in primary biliary cholangitis ( PBC ), potentially as a
result of cholestatic and/or inflammatory processes. This change is linked to systemic …

Rationale Selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine are increasingly
used for the treatment of depression in children. Limited data are, however, available on …

Förster resonance energy transfer (FRET) is a powerful biological tool for reading out cell
signaling processes. In vivo use of FRET is challenging because of the scattering properties of …

Objective Identification of patients with high-risk asymptomatic carotid plaques remains an
elusive but essential step in stroke prevention. Inflammation is a key process in plaque …

As magnetic resonance imaging (MRI) contrast agents, T1 Gd3+ chelates are generally the
preferred option for radiologists over T2 iron oxide nanoparticles. The main reason for the …