Antiamyloid antibodies have been used to reduce cerebral amyloid-beta (Aβ) load in
patients with Alzheimer’s disease. We applied focused ultrasound with each of six monthly …

The blood–brain barrier (BBB) presents a significant challenge for treating brain disorders.
The hippocampus is a key target for novel therapeutics, playing an important role in Alzheimer…

Objectives. The primary aim of this pilot investigation was to identify structural brain differences
in older adults with chronic low back pain (CLBP) as compared with pain-free individuals. …

Purpose The purpose of this study was to examine the effect of adjuvant chemotherapy on
normal-appearing white matter in women with breast cancer. Patients and Methods Ten …

BACKGROUND AND PURPOSE: To our knowledge, no published studies have examined
whole-brain regional differences to identify more discrete volumetric changes in the brains of …

… As we demonstrated, gadobutrol (molecular weight, 550 Da) pooled in perivenular spaces
after hippocampal BBB opening to surround cortical veins and the basal vein of Rosenthal. …

The blood–brain barrier (BBB) limits therapeutic delivery in Alzheimer’s disease (AD) and
other neurological disorders. Animal models have demonstrated safe BBB opening and …

OBJECTIVE MRI-guided low-intensity focused ultrasound (FUS) has been shown to
reversibly open the blood-brain barrier (BBB), with the potential to deliver therapeutic agents …

Performance on the Wisconsin Card Sorting Test (WCST) is widely reported to be impaired
in patients with schizophrenia. It has been hypothesized that the performance deficit on the …

Objective. The primary aim of this pilot study was to identify structural and functional brain
differences in older adults with self-reported disabling chronic low back pain (CLBP) compared …