Background Huntington's disease is a neurodegenerative disease of genetic origin that mainly
affects the striatum. It has severe motor and cognitive consequences and, up to now, no …

Forum Neural transplantation in putaminal 18F-dopa uptake have also been highly variable,
which suggests that differences in survival and growth of the grafted dopaminergic neurons …

The ability of a replication–deficient adenovirus vector to transfer a foreign gene into neural
cells of adult rats in vivo has been analysed. A large number of neural cells (including …

Background Although we have shown in three out of five patients with Huntington's disease
that motor and cognitive improvements 2 years after intracerebral fetal neural grafts are …

Abstract Specification of cell identity during development depends on exposure of cells to
sequences of extrinsic cues delivered at precise times and concentrations. Identification of …

The ability to preselect the donor genotype of iPSC lines provides important opportunities for
immune matching in cell therapy. Here we propose that an international assessment should …

Substitutive cell therapy using fetal striatal grafts has demonstrated preliminary clinical success
in patients with Huntington's disease, but the logistics required for accessing fetal cells …

Background Cell therapy for large burns is dependent upon autologous epidermis reconstructed
in vitro. However, the effectiveness of current procedures is limited by the delay needed …

Huntington's disease is a genetic disorder that results from degeneration of striatal neurons,
particularly those containing GABA (γ-aminobutyric acid) 1 . There is no effective treatment …

By analyzing five human embryonic stem (hES) cell lines over long-term culture, we identified
a recurrent genomic instability in the human genome. An amplification of 2.5–4.6 Mb at …