Oncogenic kinase NPM/ALK induces through STAT3 expression of immunosuppressive protein CD274 (PD-L1, B7-H1)
…, M Cheng, BA Ruggeri, MA Wasik - Proceedings of the …, 2008 - National Acad Sciences
The mechanisms of malignant cell transformation caused by the oncogenic, chimeric
nucleophosmin (NPM)/anaplastic lymphoma kinase (ALK) remain only partially understood, with …
nucleophosmin (NPM)/anaplastic lymphoma kinase (ALK) remain only partially understood, with …
[HTML][HTML] Transformation of hematopoietic cells by BCR/ABL requires activation of a PI‐3k/Akt‐dependent pathway
The BCR/ABL oncogenic tyrosine kinase activates phosphatidylinositol 3‐kinase (PI‐3k) by
a mechanism that requires binding of BCR/ABL to p85, the regulatory subunit of PI‐3k, and …
a mechanism that requires binding of BCR/ABL to p85, the regulatory subunit of PI‐3k, and …
Subcutaneous panniculitis-like T-cell lymphoma: clinicopathologic, immunophenotypic, and genotypic analysis of alpha/beta and gamma/delta subtypes
…, GK Przybylski, J Lister, MA Wasik… - The American journal …, 1998 - journals.lww.com
Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is an uncommon cutaneous lymphoma
that has been proposed as a distinct clinicopathologic entity, but studies of SPTCL are …
that has been proposed as a distinct clinicopathologic entity, but studies of SPTCL are …
Role of phosphatidylinositol 3-kinase-Akt pathway in nucleophosmin/anaplastic lymphoma kinase-mediated lymphomagenesis
…, A Morrione, M Majewski, L Xue, SW Morris, MA Wasik… - Cancer research, 2001 - AACR
The NPM/ALK fusion gene, formed by the t(2;5) translocation in a subset of anaplastic large
cell lymphomas, encodes a M r 75,000 hybrid protein that contains the NH 2 -terminal …
cell lymphomas, encodes a M r 75,000 hybrid protein that contains the NH 2 -terminal …
Multilevel dysregulation of STAT3 activation in anaplastic lymphoma kinase-positive T/null-cell lymphoma
…, N Odum, S Morris, T Skorski, MA Wasik - The Journal of …, 2002 - journals.aai.org
Accumulating evidence indicates that expression of anaplastic lymphoma kinase (ALK),
typically due to t (2; 5) translocation, defines a distinct type of T/null-cell lymphoma (TCL). The …
typically due to t (2; 5) translocation, defines a distinct type of T/null-cell lymphoma (TCL). The …
Signal transducer and activator of transcription (STAT) 5 activation by BCR/ABL is dependent on intact Src homology (SH) 3 and SH2 domains of BCR/ABL and is …
M Nieborowska-Skorska, MA Wasik… - The Journal of …, 1999 - rupress.org
Signal transducer and activator of transcription (STAT)5 is constitutively activated in BCR/
ABL-expressing cells, but the mechanisms and functional consequences of such activation are …
ABL-expressing cells, but the mechanisms and functional consequences of such activation are …
STAT3-and DNA methyltransferase 1-mediated epigenetic silencing of SHP-1 tyrosine phosphatase tumor suppressor gene in malignant T lymphocytes
…, T Nagasawa, MA Wasik - Proceedings of the …, 2005 - National Acad Sciences
Expression of SHP-1 phosphatase, a key negative regulator of cell signaling, is lost in T cell
lymphomas and other malignancies due to DNA methylation of the SHP-1 promoter by a …
lymphomas and other malignancies due to DNA methylation of the SHP-1 promoter by a …
Diagnostic microRNA profiling in cutaneous T-cell lymphoma (CTCL)
…, AM Mathiesen, K Grønbæk, MA Wasik… - Blood, The Journal …, 2011 - ashpublications.org
Cutaneous T-cell lymphomas (CTCLs) are the most frequent primary skin lymphomas.
Nevertheless, diagnosis of early disease has proven difficult because of a clinical and histologic …
Nevertheless, diagnosis of early disease has proven difficult because of a clinical and histologic …
Persistence of long-lived plasma cells and humoral immunity in individuals responding to CD19-directed CAR T-cell therapy
…, WT Hwang, SL Maude, MA Wasik… - Blood, The Journal …, 2016 - ashpublications.org
The mechanisms underlying the maintenance of long-lasting humoral immunity are not well
understood. Studies in mice indicate that plasma cells (PCs) can survive up to a lifetime, …
understood. Studies in mice indicate that plasma cells (PCs) can survive up to a lifetime, …
Activation of Jak/STAT proteins involved in signal transduction pathway mediated by receptor for interleukin 2 in malignant T lymphocytes derived from cutaneous …
…, PC Nowell, LM Shaw, MA Wasik - Proceedings of the …, 1996 - National Acad Sciences
Signaling through the interleukin 2 receptor (IL-2R) involves phosphorylation of several
proteins including Jak3, STAT5, and, in preactivated cells, STAT3. In the present study, we …
proteins including Jak3, STAT5, and, in preactivated cells, STAT3. In the present study, we …