Although it is being successfully implemented for exploration of the genome, discovery
science has eluded the functional neuroimaging community. The core challenge remains the …

BACKGROUND: Functional imaging studies indicate that imbalances in cortico-limbic activity
and connectivity may underlie the pathophysiology of MDD. In this study, using functional …

Cross-correlation of low-frequency temporal fluctuations (<0.08 Hz) was used to correlate
widely separated anatomic regions during continuous performance of a spatial working …

This study for the first time investigated resting state corticolimbic connectivity abnormalities
in unmedicated bipolar disorder (BD) and compared them with findings in healthy controls …

The mechanisms by which antidepressant-induced neurochemical changes lead to physiological
changes in brain circuitry and ultimately an antidepressant response remain unclear. …

Removal of the anterior temporal lobe (ATL) is an effective surgical treatment for intractable
temporal lobe epilepsy but carries a risk of language and verbal memory deficits. …

PURPOSE: To study the correlation of low-frequency blood oxygenation level–dependent (BOLD)
fluctuations on magnetic resonance (MR) images obtained of the left- and right-…

ECHO-PLANAR functional magnetic resonance imaging (EP-fMRI) was used to study the
activity of the amygdalae while three normal female subjects viewed alternating blocks of …

Background There are limited treatments for progressive multiple sclerosis. Ibudilast inhibits
several cyclic nucleotide phosphodiesterases, macrophage migration inhibitory factor, and …

PURPOSE: To determine the clinical utility of gadolinium-enhanced fluid-attenuated
inversion-recovery (FLAIR) magnetic resonance (MR) imaging of the brain by comparing results …