Background Ofatumumab, a subcutaneous anti-CD20 monoclonal antibody, selectively
depletes B cells. Teriflunomide, an oral inhibitor of pyrimidine synthesis, reduces T-cell and B-…

Background No treatments have been approved for primary progressive multiple sclerosis.
Fingolimod, an oral sphingosine 1-phosphate receptor modulator, is effective in relapse-…

We propose a histopathological classification system for hippocampal cell loss in patients
suffering from mesial temporal lobe epilepsies (MTLE). One hundred and seventy-eight …

We studied a patient with idiopathic generalized epilepsy and frequent absences, using
electroencephalogram‐correlated functional magnetic resonance imaging. Four prolonged runs …

Background Treatment of patients younger than 18 years of age with multiple sclerosis has
not been adequately examined in randomized trials. We compared fingolimod with interferon …

Using continuous EEG-correlated fMRI, we investigated the Blood Oxygen Level Dependent
(BOLD) signal correlates of interictal epileptic discharges (IEDs) in 63 consecutively …

Objective We describe the characteristics of the 15 patients with fingolimod-associated
progressive multifocal leukoencephalopathy (PML) identified from the Novartis data safety base …

Hippocampal specimens resected to cure medically intractable temporal lobe epilepsy (TLE)
provide a unique possibility to study functional consequences of morphological alterations. …

The dentate gyrus (DG) plays a pivotal role in the functional and anatomical organization of
the hippocampus and is involved in learning and memory formation. However, the impact of …

AFQ056 is a novel, selective metabotropic glutamate receptor 5 antagonist. This was a 13‐week,
double‐blind, placebo‐controlled study. Patients with Parkinson's disease and …