Endothelium-dependent relaxations are achieved by a combination of endothelium-derived
prostacyclin (PGI 2), nitric oxide (NO), and endothelium-derived hyperpolarizing factor (…

Background and Purpose—We estimated the incidence of first-ever cerebral infarction in
regard to its subtypes and analyzed their risk factors separately in a community-based …

We studied the mechanism of hemorrhagic infarction after acute cerebral embolism in 160
patients by brain computed tomography and angiography. Hemorrhagic infarction during the …

To elucidate the effect of glucose intolerance on cardiovascular disease in the current
Japanese population, we performed a 75-g oral glucose tolerance test in 2,427 Hisayama …

Adriamycin-induced nephropathy as a model of chronic progressive glomerular disease.
Serial changes in urine protein, blood chemistry, and histology of the kidney were investigated …

We investigated seasonal variation in the incidence of cerebral stroke among the general
population aged greater than or equal to 40 years in November of 1961 in Hisayama, Japan. …

BACKGROUND Few previous articles have analyzed the relation between infection with
Helicobacter pylori (H. pylori) and primary gastric lymphoma in a large number of patients. …

A multicenter double-blind placebo-controlled study of cytidine 5'-diphosphocholine (CDP-choline)
was conducted to evaluate possible clinical benefits of the drug in patients with acute…

Endoscopic and biopsy findings of the esophagus, stomach, duodenum, and colorectum
were studied in 37 patients with amyloidosis involving the gastrointestinal tract. Endoscopic …

Background and Purpose—Subarachnoid hemorrhage is a life-threatening disease that
occurs mostly because of the rupture of intracranial saccular aneurysms. However, little is …