Growth retardation resulting in short stature is a major concern for parents and due to its great
variety of causes, a complex diagnostic challenge for clinicians. A major locus involved in …

The relationship between 24-h GH secretion, insulin-like growth factor (IGF) I serum levels,
IGF-binding protein 3 (IGFBP-3) levels and height was studied in 114 healthy children and …

It has been known since the late 1950s that GH isolated from the pituitaries of humans and
anthropoid apes was capable of stimulating growth in children with deficient GH secretion (l-3)…

Background: Analysis of insulin-like growth factor I in serum (S-IGF-I) is an integral component
in the diagnosis of GH-related disorders and is going to be of interest in the diagnosis and …

Before chromosomal analysis became available, the diagnosis of Turner's syndrome was
based on the characteristics independently described by Otto Ullrich and Henry Turner, such …

Background Some studies have suggested that treatment with recombinant human growth
hormone (rhGH) increases left-ventricular mass and improves haemodynamic and functional …

Background Growth hormone (GH) contributes to insulin resistance, but whether children
treated with GH are at increased risk of diabetes has not been established. We undertook a …

Assays for insulin-like growth factor I (IGF-I) and IGF-binding protein 3 (IGFBP-3) have become
essential tools in the diagnostic work-up of disorders of the somatotropic axis in children …

Postmarketing surveillance studies of recombinant human GH therapy, such as the Kabi
Pharmacia International Growth Study (KIGS; Pharmacia & Upjohn, Inc., International Growth …

The acid-stable subunit of the GH-dependent large mol wt somatomedin-binding protein (SmBP)
was isolated from human plasma Cohn fraction IV by a three-step procedure, and a …