Immunotherapy is a promising area of therapy in patients with neuro-oncological malignancies.
However, early-phase studies show unique challenges associated with the assessment …

… Although extracellular signal-regulated kinases pathways promote cell survival and
proliferation, and c-Jun N-terminal protein kinases/p38 pathways induce apoptosis in general, the …

… In this prospective study, we analysed the development of thyroid dysfunction in a large
number of patients (n = 209) treated with anti-PD-1 antibodies, and showed that the presence of …

Purpose: This study was conducted to investigate the effect of low‐frequency electric cortical
stimulation on epileptic focus in humans. Methods: We stimulated the epileptic focus in a …

… 2 (1 − f)/f} 0.5 ), where R n is the intrinsic 1/T 1 of water in the brain, k n is the rate constant
of diffusive water influx from the Gd-DTPA–nonaccessible space into the accessible space, f …

… The N-terminal truncated product created by the disruption should contain kinase subdomains
I-IV, but this product should have no kinase activity". The C terminus should be expressed …

… The intensities of the optical density of the representative section from each reaction (n = 3)
were summed. The intensity values are expressed as mean ± sem (n = 3). We use the term '…

The origin of fibroblasts in pulmonary fibrosis is assumed to be intrapulmonary, but their
extrapulmonary origin and especially derivation from bone marrow (BM) progenitor cells has not …

Parkinson disease (PD) is a neurodegenerative disorder characterized by loss of midbrain
dopaminergic (DA) neurons. ES cells are currently the most promising donor cell source for …

Background Moyamoya disease is an idiopathic vascular disorder of intracranial arteries. Its
susceptibility locus has been mapped to 17q25.3 in Japanese families, but the susceptibility …