User profiles for N. Uchida

Naoshige Uchida

Professor of Molecular and Cellular Biology, Harvard University
Verified email at mcb.harvard.edu
Cited by 16048

The biology of hematopoietic stem cells

SJ Morrison, N Uchida… - Annual review of cell and …, 1995 - annualreviews.org
36 MORRISON, UCHIDA & WEISSMAN more HSC. In mouse and human, HSC represent
up to 0.05% of cells in the bone marrow. HSC are almost entirely responsible for the …

Family Systems Theory, Attachment Theory, and Culture*

F Rothbaum, K Rosen, T Ujiie, N Uchida - Family process, 2002 - Wiley Online Library
Family systems theory and attachment theory have important similarities and complementarities.
Here we consider two areas in which the theories converge: (a) in family system …

Neural circuitry of reward prediction error

…, N Eshel, N Uchida - Annual review of …, 2017 - annualreviews.org
Dopamine neurons facilitate learning by calculating reward prediction error, or the difference
between expected and actual reward. Despite two decades of research, it remains unclear …

Direct isolation of human central nervous system stem cells

N Uchida, DW Buck, D He… - Proceedings of the …, 2000 - National Acad Sciences
… In addition, many of these cells in the RMS expressed the human specific marker N-CAM
(… Some of these cells expressed human N-CAM, indicating that they were committed to …

Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region

…, T Miyamoto, B Lyons, K Ohshima, N Uchida… - Nature …, 2007 - nature.com
… -C–treated AML-engrafted mouse bone marrow (n = 3). Two sets of representative plots are
… (d) Cell cycle status of LS cells and non-stem fractions in AML-engrafted recipients (n = 5). A …

Neuron-type-specific signals for reward and punishment in the ventral tegmental area

JY Cohen, S Haesler, L Vong, BB Lowell, N Uchida - nature, 2012 - nature.com
Dopamine has a central role in motivation and reward. Dopaminergic neurons in the ventral
tegmental area (VTA) signal the discrepancy between expected and actual rewards (that is, …

[PDF][PDF] Whole-brain mapping of direct inputs to midbrain dopamine neurons

…, L Zhu, SK Ogawa, A Vamanrao, N Uchida - Neuron, 2012 - cell.com
… Furthermore, we have verified that the patterns of labeling are similar at 5 days (n = 3 mice,
VTA) and 9 days (n = 2 mice, VTA) after the injection of SADDG-GFP(EnvA) compared to the …

Transplanted human fetal neural stem cells survive, migrate, and differentiate in ischemic rat cerebral cortex

…, MA Yenari, IL Weissman, N Uchida… - Proceedings of the …, 2004 - National Acad Sciences
We characterize the survival, migration, and differentiation of human neurospheres derived
from CNS stem cells transplanted into the ischemic cortex of rats 7 days after distal middle …

CRISPR/Cas9 β-globin gene targeting in human haematopoietic stem cells

…, N Saxena, AB Wilkens, S Mantri, N Uchida… - Nature, 2016 - nature.com
… (n = 4 different SCD patient donors). b, HBB-targeted SCD HSPCs were analysed for GFP
expression by flow cytometry (n = 4 … of three different HSPC donors (n = 3 different SCD patient …

Odor maps in the mammalian olfactory bulb: domain organization and odorant structural features

N Uchida, YK Takahashi, M Tanifuji, K Mori - Nature neuroscience, 2000 - nature.com
… acids (n = 13 rats), aliphatic aldehydes (n = 13), alcohols (n = 7) and straight chain alkanes
(n = 7). … In all OBs examined (n = 10), we consistently observed this gradual shift of activated …