Psychiatry research has long experienced a stagnation stemming from a lack of understanding
of the neurobiological underpinnings of phenomenologically defined mental disorders. …

Oligomeric forms of amyloid-β peptide (Aβ) are thought to play a pivotal role in the
pathogenesis of Alzheimer's disease (AD), but the mechanism involved is still unclear. Here, we …

Psychiatric research has been hampered by an explanatory gap between psychiatric
symptoms and their neural underpinnings, which has resulted in poor treatment outcomes. This …

Subcortical structures, which include the basal ganglia and parts of the limbic system, have
key roles in learning, motor control and emotion, but also contribute to higher-order executive …

Functional near-infrared spectroscopy (fNIRS) is a relatively new technique that can measure
hemoglobin changes in brain tissues, and its use in psychiatry has been progressing …

… neutral (G − N) and embarrassment minus neutral (E − N). A … N contrast in the random effect
analysis (threshold at P < 0.001, uncorrected). This mask was applied inclusively to the E − N …

… specified (PDD-NOS) (n=24, n=3 and n=8, respectively) were supported by ADOS 47 (…
Suppose that we have N observations of the paired variables and . Let denote the N × p 1 …

Near-infrared spectroscopy (NIRS) is commonly used for studying human brain function.
However, several studies have shown that superficial hemodynamic changes such as skin …

… 2 Lengths of TRFs in peripheral mononuclear cells obtained from healthy volunteers (n=80;
aged 4–95 years old). The vertical axis shows the TRF length (kilobases) and the horizontal …

… In the amyloidogenic pathway, β-secretase, β-site APP cleaving enzyme 1 (BACE1), cleaves
APP on the N-terminal side of the Aβ domain to soluble sAPPβ and APP-CTFβ (Figure 3). …