The brain is in many ways an immunologically and pharmacologically privileged site. The
blood–brain barrier (BBB) of the cerebrovascular endothelium and its participation in the …

Contrast-enhanced magnetic resonance imaging is a commonly used diagnostic tool.
Compared with standard gadolinium-based contrast agents, ferumoxytol (Feraheme, AMAG …

The blood–brain barrier (BBB) limits drug delivery to brain tumors. We utilize intraarterial
infusion of hyperosmotic mannitol to reversibly open the BBB by shrinking endothelial cells and …

BACKGROUND The aim of this study was to determine the safety and efficacy of intraarterial
chemotherapy with osmotic opening of the blood‐brain barrier (BBB) for the treatment of …

Background: Primary intraocular lymphoma (PIOL) is an uncommon subset of primary central
nervous system lymphoma. Because it is rare and difficult to diagnose, the natural history …

PURPOSE: To evaluate the safety and efficacy of intravitreal methotrexate in the management
of primary central nervous system lymphoma (PCNSL) involving the eye. DESIGN: …

Purpose Primary CNS lymphoma (PCNSL) is confined to the CNS and/or the eyes at presentation
and is usually initially treated with intravenous methotrexate-based chemotherapy and …

OBJECTIVE: Patients with non-acquired immunodeficiency syndrome-related primary central
nervous system lymphomas have the potential to achieve durable complete responses …

Objective: To describe and correlate neurotoxicity indicators in long-term primary CNS
lymphoma (PCNSL) survivors who were treated with high-dose methotrexate–based regimens …

Dosing and route of administration of N-acetylcysteine (NAC) for protection against cisplatin
(CDDP) nephrotoxicity was investigated in rats. Two models of toxicity were tested: a single …