Mice experiencing repeated aggression develop a long-lasting aversion to social contact,
which can be normalized by chronic, but not acute, administration of antidepressant. Using …

To better understand the molecular mechanisms of depression and antidepressant action,
we administered chronic social defeat stress followed by chronic imipramine (a tricyclic …

Given that cocaine induces neuroadaptations through regulation of gene expression, we
investigated whether chromatin remodeling at specific gene promoters may be a key …

… One-micron toluidine-stained scout sections were prepared for light microscopic orientation;
80 nm ultrathin sections for EM were stained with uranyl acetate and lead citrate and …

The mechanism of action of electroconvulsive seizures (ECS), one of the most effective
treatments of major depression, may involve the regulation of gene expression. Chromatin …

… Electron microscopy studies revealed the presence of multiple spherical virus particles
showing spike-like electron-dense peplomeric projections ranging from 100-to-140 nm (Figure 1B…

To examine the diversity of astrocytes in the human brain, we immunostained surgical
specimens of temporal cortex and hippocampus and autopsy brains for CD44, a plasma …

Research on human pluripotent stem cells has been hampered by the lack of a standardized,
quantitative, scalable assay of pluripotency. We previously described an assay called …

Myeloid cells comprise the majority of immune cells in tumors, contributing to tumor growth
and therapeutic resistance. Incomplete understanding of myeloid cells response to tumor …

Chromosomal instability (CIN) is a fundamental property of cancer and a key underlying
mechanism of tumorigenesis and malignant progression, and has been documented in a wide …