Accumulating evidence suggests a role for microRNAs in human carcinogenesis as novel
types of tumor suppressors or oncogenes. However, their precise biological role remains …

Purpose Exosomal microRNAs (miRNAs) have been attracting major interest as potential
diagnostic biomarkers of cancer. The aim of this study was to characterize the miRNA profiles …

Purpose: To investigate the safety and the immunologic and clinical responses of dendritic
cell therapy for patients with recurrent malignant glioma. Experimental Design: Twenty-four …

Selective activation of p53 target genes in response to various cellular stresses is a critical
step in determining the ability to induce cell-cycle arrest or apoptosis. Here we report the …

Colon cancers have been shown to develop after accumulation of multiple genetic and
epigenetic alterations with changes in global gene expression profiles, contributing to the …

Introduction: Up to 30% stage I lung cancer patients suffer recurrence within 5 years of curative
surgery. We sought to improve existing protein-coding gene and microRNA expression …

The mouse hypervariable minisatellite (MN) Pc-1 consists of tandem repeats of d(GGCAG)
and flanked sequences. We have previously demonstrated that single-stranded d(GGCAG) n …

Purpose: The primary goal of this phase I study was to assess the safety and immunologic
responses of personalized peptide vaccination for patients with advanced malignant glioma. …

Due to their rarity and diversity, sarcomas are difficult to diagnose. Consequently, there is an
urgent demand for a novel diagnostic test for these cancers. In this study, we investigated …

We have previously reported that the heterogeneous nuclear ribonucleoprotein A1 (hnRNP
A1), a major hnRNP, binds to G-rich repetitive sequences and quadruplex (G4') structures in …