Impairment of insulin signaling in the brain has been linked to neurodegenerative diseases.
To test the hypothesis that neuronal insulin resistance contributes to defects in neuronal …

This guideline provides recommendations for the use of PET imaging in gliomas. The
review examines established clinical benefit in glioma patients of PET using glucose ( 18 F-FDG) …

Highlights • This Clinical Practice Guideline provides management recommendations for
patients with brain metastases from solid tumours. • The guideline covers clinical and …

Background There is an urgent need for more effective therapies for glioblastoma. Data
from a previous unrandomised phase 2 trial suggested that lomustine-temozolomide plus …

These joint practice guidelines, or procedure standards, were developed collaboratively by
the European Association of Nuclear Medicine (EANM), the Society of Nuclear Medicine and …

Despite the fact that MRI has evolved to become the standard method for diagnosis and
monitoring of patients with brain tumours, conventional MRI sequences have two key limitations: …

Locus ceruleus (LC) degeneration and loss of cortical noradrenergic innervation occur early
in Alzheimer’s disease (AD). Although this has been known for several decades, the …

Because of the high glucose metabolism in normal brain tissue 18 F-FDG is not the ideal
tracer for the detection of gliomas. Methyl- 11 C-l-methionine ( 11 C-MET) is better suited for …

Purpose The follow-up of glioblastoma patients after radiochemotherapy with conventional
MRI can be difficult since reactive alterations to the blood–brain barrier with contrast …

The assessment of treatment response in glioblastoma is difficult with MRI because reactive
blood–brain barrier alterations with contrast enhancement can mimic tumor progression. In …