Drug development for CNS disorders: strategies for balancing risk and reducing attrition
MN Pangalos, LE Schechter, O Hurko - Nature Reviews Drug Discovery, 2007 - nature.com
Disorders of the central nervous system (CNS) are some of the most prevalent, devastating
and yet poorly treated illnesses. The development of new therapies for CNS disorders such …
and yet poorly treated illnesses. The development of new therapies for CNS disorders such …
Pharmacologic interventions for stroke: looking beyond the thrombolysis time window into the penumbra with biomarkers, not a stopwatch
JC Chavez, O Hurko, FC Barone, GZ Feuerstein - Stroke, 2009 - Am Heart Assoc
Background and Purpose— The majority of pharmacological agents for stroke were developed
based on the assumption that neurological deficits will be reduced upon the successful …
based on the assumption that neurological deficits will be reduced upon the successful …
MELAS mutation in mtDNA binding site for transcription termination factor causes defects in protein synthesis and in respiration but no change in levels of upstream …
…, M Yoneda, A Daga, O Hurko… - Proceedings of the …, 1992 - National Acad Sciences
The pathogenetic mechanism of the mitochondrial tRNA(LeuUUR) gene mutation responsible
for the MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like …
for the MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like …
Translational research in central nervous system drug discovery
O Hurko, JL Ryan - NeuroRx, 2005 - Elsevier
Of all the therapeutic areas, diseases of the CNS provide the biggest challenges to
translational research in this era of increased productivity and novel targets. Risk reduction by …
translational research in this era of increased productivity and novel targets. Risk reduction by …
Marked replicative advantage of human mtDNA carrying a point mutation that causes the MELAS encephalomyopathy.
…, A Chomyn, A Martinuzzi, O Hurko… - Proceedings of the …, 1992 - National Acad Sciences
… Subcloning was carried out by mixing samples of =20 cells from each transformant with
105 p206 cells in DMEM with10%o fetal calf serum andbromodeoxyuridine at 100 pg/ml and …
105 p206 cells in DMEM with10%o fetal calf serum andbromodeoxyuridine at 100 pg/ml and …
Schizophrenia-related neural and behavioral phenotypes in transgenic mice expressing truncated Disc1
…, NJ Brandon, KL Marquis, M Day, O Hurko… - Journal of …, 2008 - Soc Neuroscience
Disrupted-in-Schizophrenia-1 (DISC1), identified by positional cloning of a balanced translocation
(1;11) with the breakpoint in intron 8 of a large Scottish pedigree, is associated with a …
(1;11) with the breakpoint in intron 8 of a large Scottish pedigree, is associated with a …
Family study and segregation analysis of Tourette syndrome: evidence for a mixed model of inheritance.
…, HS Singer, J Brown, MA Riddle, O Hurko - American journal of …, 1996 - ncbi.nlm.nih.gov
… and OCD was completed on each proband and family member by a panel consisting of a
child psychiatrist (JTW), a pediatric neurologist (HSS) and an adult neurologist/geneticist (OH). …
child psychiatrist (JTW), a pediatric neurologist (HSS) and an adult neurologist/geneticist (OH). …
[HTML][HTML] Respiration and growth defects in transmitochondrial cell lines carrying the 11778 mutation associated with Leber's hereditary optic neuropathy
G Hofhaus, DR Johns, O Hurko, G Attardi… - Journal of Biological …, 1996 - ASBMB
… the total O 2 consumption rate in the intact ρ 0 transformant cells containing the 11778
mutation, in the control transformants, and in 143B cells. There is appreciable variation in O 2 …
mutation, in the control transformants, and in 143B cells. There is appreciable variation in O 2 …
Abnormal fatty acid metabolism in childhood spinal muscular atrophy
TO Crawford, JT Sladky, O Hurko… - Annals of Neurology …, 1999 - Wiley Online Library
Our previous experience with abnormal fatty acid metabolism in several children with spinal
muscular atrophy (SMA) prompted evaluation of fatty acid metabolism in a larger cohort. …
muscular atrophy (SMA) prompted evaluation of fatty acid metabolism in a larger cohort. …
[HTML][HTML] Sleep-disordered breathing in children with achondroplasia
PJ Mogayzel Jr, JL Carroll, GM Loughlin, O Hurko… - The Journal of …, 1998 - Elsevier
… The mean S a O 2 and the S a O 2 nadir were quantitated. The mean S a O 2 was estimated
by visualization of each epoch. S a O 2 measurements associated with poor pulse tracings …
by visualization of each epoch. S a O 2 measurements associated with poor pulse tracings …