Estimating kinetic parameters from dynamic contrast‐enhanced t1‐weighted MRI of a diffusable tracer: Standardized quantities and symbols

PS Tofts, G Brix, DL Buckley… - Journal of Magnetic …, 1999 - Wiley Online Library
… the PS-limited case, for relatively small molecules such as … - and PS-limited case; however,
in the brain most cases are PS limited… Tofts PS. Standardisation and optimisation of magnetic …

Modeling tracer kinetics in dynamic Gd‐DTPA MR imaging

PS Tofts - Journal of magnetic resonance imaging, 1997 - Wiley Online Library
… Larsson HEW, Tofts PS. Measurement of blood brain barrier permeability using dynamic
Gd-DTPA scanning: a comparison of methods. Magn Reson Med 1992; 24:174-176. …

[HTML][HTML] Imaging biomarker roadmap for cancer studies

…, DC Sullivan, SA Taylor, PS Tofts… - Nature reviews Clinical …, 2017 - nature.com
Imaging biomarkers (IBs) are integral to the routine management of patients with cancer. IBs
used daily in oncology include clinical TNM stage, objective response and left ventricular …

Measurement of the blood‐brain barrier permeability and leakage space using dynamic MR imaging. 1. Fundamental concepts

PS Tofts, AG Kermode - Magnetic resonance in medicine, 1991 - Wiley Online Library
… where k = PS/V, is the permeability surface area product per unit volume of tissue, or transfer
coefficient, with units of [min-'1 (11). Our Eq. [4] differs slightly from the conventional one …

Spinal cord atrophy and disability in multiple sclerosis: a new reproducible and sensitive MRI method with potential to monitor disease progression

…, JI O'riordan, R Page, L Wang, GJ Barker, PS Tofts… - Brain, 1996 - academic.oup.com
Recent MRI studies in multiple sclerosis have highlighted the potential importance of spinal
cord atrophy (implicating axonal loss) in the development of disability. However, the …

Quantitative analysis of dynamic Gd‐DTPA enhancement in breast tumors using a permeability model

PS Tofts, B Berkowitz… - Magnetic resonance in …, 1995 - Wiley Online Library
… We find a physiological model for measuring capillary permeability and leakage space (PS
Tofts, AG Kermode, measurement of the blood-brain barrier permeability and leakage space …

Serial proton magnetic resonance spectroscopy in acute multiple sclerosis lesions

CA Davie, CP Hawkins, GJ Barker, A Brennan, PS Tofts… - Brain, 1994 - academic.oup.com
Serial proton magnetic resonance spectroscopy (MRS), was carried out at 1–2 monthly
intervals on eight patients with multiple sclerosis who presented with evidence of a large acute …

[HTML][HTML] The assessment of antiangiogenic and antivascular therapies in early-stage clinical trials using magnetic resonance imaging: issues and recommendations

…, P Price, R Rathbone, GJ Rustin, PS Tofts… - British journal of …, 2005 - nature.com
Vascular and angiogenic processes provide an important target for novel cancer therapeutics.
Dynamic contrast-enhanced magnetic resonance imaging is being used increasingly to …

Normal cerebral perfusion measurements using arterial spin labeling: reproducibility, stability, and age and gender effects

…, W Rashid, DT Chard, PS Tofts - Magnetic Resonance in …, 2004 - Wiley Online Library
… The fixed model parameters were: PS/v bw = 1.5/0.05 min –1 , where PS is the permeability
surface area product for water, and v bw is the fractional blood water volume per unit volume …

The role of NMR imaging in the assessment of multiple sclerosis and isolated neurological lesions: a quantitative study

…, BE Kendall, IF Moseley, G Johnson, PS Tofts… - Brain, 1987 - academic.oup.com
The form and distribution of MRI abnormalities in 114 patients with clinically definite multiple
sclerosis (MS) have been compared with observations on 53 apparently healthy individuals, …