Estimating kinetic parameters from dynamic contrast‐enhanced t1‐weighted MRI of a diffusable tracer: Standardized quantities and symbols
PS Tofts, G Brix, DL Buckley… - Journal of Magnetic …, 1999 - Wiley Online Library
… the PS-limited case, for relatively small molecules such as … - and PS-limited case; however,
in the brain most cases are PS limited… Tofts PS. Standardisation and optimisation of magnetic …
in the brain most cases are PS limited… Tofts PS. Standardisation and optimisation of magnetic …
Modeling tracer kinetics in dynamic Gd‐DTPA MR imaging
PS Tofts - Journal of magnetic resonance imaging, 1997 - Wiley Online Library
… Larsson HEW, Tofts PS. Measurement of blood brain barrier permeability using dynamic
Gd-DTPA scanning: a comparison of methods. Magn Reson Med 1992; 24:174-176. …
Gd-DTPA scanning: a comparison of methods. Magn Reson Med 1992; 24:174-176. …
[HTML][HTML] Imaging biomarker roadmap for cancer studies
…, DC Sullivan, SA Taylor, PS Tofts… - Nature reviews Clinical …, 2017 - nature.com
Imaging biomarkers (IBs) are integral to the routine management of patients with cancer. IBs
used daily in oncology include clinical TNM stage, objective response and left ventricular …
used daily in oncology include clinical TNM stage, objective response and left ventricular …
Measurement of the blood‐brain barrier permeability and leakage space using dynamic MR imaging. 1. Fundamental concepts
PS Tofts, AG Kermode - Magnetic resonance in medicine, 1991 - Wiley Online Library
… where k = PS/V, is the permeability surface area product per unit volume of tissue, or transfer
coefficient, with units of [min-'1 (11). Our Eq. [4] differs slightly from the conventional one …
coefficient, with units of [min-'1 (11). Our Eq. [4] differs slightly from the conventional one …
Spinal cord atrophy and disability in multiple sclerosis: a new reproducible and sensitive MRI method with potential to monitor disease progression
Recent MRI studies in multiple sclerosis have highlighted the potential importance of spinal
cord atrophy (implicating axonal loss) in the development of disability. However, the …
cord atrophy (implicating axonal loss) in the development of disability. However, the …
Quantitative analysis of dynamic Gd‐DTPA enhancement in breast tumors using a permeability model
PS Tofts, B Berkowitz… - Magnetic resonance in …, 1995 - Wiley Online Library
… We find a physiological model for measuring capillary permeability and leakage space (PS
Tofts, AG Kermode, measurement of the blood-brain barrier permeability and leakage space …
Tofts, AG Kermode, measurement of the blood-brain barrier permeability and leakage space …
Serial proton magnetic resonance spectroscopy in acute multiple sclerosis lesions
Serial proton magnetic resonance spectroscopy (MRS), was carried out at 1–2 monthly
intervals on eight patients with multiple sclerosis who presented with evidence of a large acute …
intervals on eight patients with multiple sclerosis who presented with evidence of a large acute …
[HTML][HTML] The assessment of antiangiogenic and antivascular therapies in early-stage clinical trials using magnetic resonance imaging: issues and recommendations
Vascular and angiogenic processes provide an important target for novel cancer therapeutics.
Dynamic contrast-enhanced magnetic resonance imaging is being used increasingly to …
Dynamic contrast-enhanced magnetic resonance imaging is being used increasingly to …
Normal cerebral perfusion measurements using arterial spin labeling: reproducibility, stability, and age and gender effects
…, W Rashid, DT Chard, PS Tofts - Magnetic Resonance in …, 2004 - Wiley Online Library
… The fixed model parameters were: PS/v bw = 1.5/0.05 min –1 , where PS is the permeability
surface area product for water, and v bw is the fractional blood water volume per unit volume …
surface area product for water, and v bw is the fractional blood water volume per unit volume …
The role of NMR imaging in the assessment of multiple sclerosis and isolated neurological lesions: a quantitative study
…, BE Kendall, IF Moseley, G Johnson, PS Tofts… - Brain, 1987 - academic.oup.com
The form and distribution of MRI abnormalities in 114 patients with clinically definite multiple
sclerosis (MS) have been compared with observations on 53 apparently healthy individuals, …
sclerosis (MS) have been compared with observations on 53 apparently healthy individuals, …