User profiles for P. Dusek
 | Petr DušekDepartment of Neurology and Center of Clinical Neuroscience, Charles University, 1st … Verified email at vfn.cz Cited by 5543 |
Wilson disease
… Petr Dusek … In 1993, the gene associated with WD, ATP7B, was located to
chromosome 13q and found to code a P-type ATPase involved in copper transport 209 . …
chromosome 13q and found to code a P-type ATPase involved in copper transport 209 . …
Biomarkers of conversion to α-synucleinopathy in isolated rapid-eye-movement sleep behaviour disorder
…, NJ Diederich, K Doppler, P Dušek… - The Lancet …, 2021 - thelancet.com
Patients with isolated rapid-eye-movement sleep behaviour disorder (RBD) are commonly
regarded as being in the early stages of a progressive neurodegenerative disease involving α…
regarded as being in the early stages of a progressive neurodegenerative disease involving α…
The neurotoxicity of iron, copper and manganese in Parkinson's and Wilson's diseases
Impaired cellular homeostasis of metals, particularly of Cu, Fe and Mn may trigger
neurodegeneration through various mechanisms, notably induction of oxidative stress, promotion of …
neurodegeneration through various mechanisms, notably induction of oxidative stress, promotion of …
Risk and predictors of dementia and parkinsonism in idiopathic REM sleep behaviour disorder: a multicentre study
Idiopathic REM sleep behaviour disorder (iRBD) is a powerful early sign of Parkinson’s
disease, dementia with Lewy bodies, and multiple system atrophy. This provides an …
disease, dementia with Lewy bodies, and multiple system atrophy. This provides an …
[HTML][HTML] Trial of deferiprone in Parkinson's disease
Background Iron content is increased in the substantia nigra of persons with Parkinson’s
disease and may contribute to the pathophysiology of the disorder. Early research suggests that …
disease and may contribute to the pathophysiology of the disorder. Early research suggests that …
Speech biomarkers in rapid eye movement sleep behavior disorder and Parkinson disease
… controls for monopitch (p < 0.001), prolonged pauses (p < 0.001), and imprecise consonants
(p = 0.03); only monopitch was able to differentiate iRBD patients from controls (p = 0.004). …
(p = 0.03); only monopitch was able to differentiate iRBD patients from controls (p = 0.004). …
Progression of clinical markers in prodromal Parkinson's disease and dementia with Lewy bodies: a multicentre study
The neurodegenerative synucleinopathies, including Parkinson’s disease and dementia
with Lewy bodies, are characterized by a typically lengthy prodromal period of progressive …
with Lewy bodies, are characterized by a typically lengthy prodromal period of progressive …
Iron dysregulation in movement disorders
P Dusek, J Jankovic, W Le - Neurobiology of disease, 2012 - Elsevier
Iron is an essential element necessary for energy production, DNA and neurotransmitter
synthesis, myelination and phospholipid metabolism. Neurodegeneration with brain iron …
synthesis, myelination and phospholipid metabolism. Neurodegeneration with brain iron …
Safety and efficacy of deferiprone for pantothenate kinase-associated neurodegeneration: a randomised, double-blind, controlled trial and an open-label extension …
…, C Küpper, C Neuhofer, B Kálmán, P Dušek… - The Lancet …, 2019 - thelancet.com
Background Pantothenate kinase-associated neurodegeneration (PKAN) is a rare genetic
disorder characterised by progressive generalised dystonia and brain iron accumulation. We …
disorder characterised by progressive generalised dystonia and brain iron accumulation. We …
Genetics and pathophysiology of neurodegeneration with brain iron accumulation (NBIA)
SA Schneider, P Dusek, J Hardy… - Current …, 2013 - ingentaconnect.com
Our understanding of the syndromes of Neurodegeneration with Brain Iron Accumulation (NBIA)
continues to grow considerably. In addition to the core syndromes of pantothenate …
continues to grow considerably. In addition to the core syndromes of pantothenate …