… Calabresi has received personal compensation for consulting and serving on scientific
advisory boards from Vertex, Vaccinex, Medimmune, Prothena, and Abbott, and has received …

Optical coherence tomography (OCT) is a new method that could aid analysis of neurodegeneration
in multiple sclerosis (MS) by capturing thinning of the retinal nerve fibre layer (RNFL)…

Background Structural retinal imaging biomarkers are important for early recognition and
monitoring of inflammation and neurodegeneration in multiple sclerosis. With the introduction …

Background Interferon beta is used to modify the course of relapsing multiple sclerosis.
Despite interferon beta therapy, many patients have relapses. Natalizumab, an α 4 integrin …

Diffusion tensor imaging (DTI) is an exciting new MRI modality that can reveal detailed anatomy
of the white matter. DTI also allows us to approximate the 3D trajectories of major white …

Multiple sclerosis (MS) lesions that do not resolve in the months after they form harbour
ongoing demyelination and axon degeneration, and are identifiable in vivo by their …

Objective Rituximab, a monoclonal antibody selectively depleting CD20+ B cells, has
demonstrated efficacy in reducing disease activity in relapsing‐remitting multiple sclerosis (MS). …

Background B lymphocytes are implicated in the pathogenesis of multiple sclerosis. We
aimed to assess efficacy and safety of two dose regimens of the humanised anti-CD20 …

Background Fingolimod has shown reductions in clinical and MRI disease activity in patients
with relapsing-remitting multiple sclerosis. We further assessed the efficacy and safety of …

PURPOSE: To examine the relation of visual function to retinal nerve fiber layer (RNFL)
thickness as a structural biomarker for axonal loss in multiple sclerosis (MS), and to compare …