The Morris water maze (MWM) was described 20 years ago as a device to investigate spatial
learning and memory in laboratory rats. In the meanwhile, it has become one of the most …

… Smet , Griet Glorieux , Angel Argilés , Ulrich Baurmeister , Philippe Brunet , William Clark
, Gerald Cohen , Peter Paul De Deyn , Reinhold Deppisch , Beatrice Descamps-Latscha , …

There is an urgent need for improved diagnostics and therapeutics for acute ischemic stroke.
This is the focus of numerous research projects involving in vitro studies, animal models …

Abstract Characterization of the genetic landscape of Alzheimer’s disease (AD) and related
dementias (ADD) provides a unique opportunity for a better understanding of the associated …

We undertook a two-stage genome-wide association study (GWAS) of Alzheimer's disease (AD)
involving over 16,000 individuals, the most powerful AD GWAS to date. In stage 1 (3,941 …

We sought to identify new susceptibility loci for Alzheimer's disease through a staged
association study (GERAD+) and by testing suggestive loci reported by the Alzheimer's Disease …

Background There is debate about whether the initial treatment for patients with Parkinson's
disease should be levodopa or a dopamine agonist. Methods In this prospective, …

Risk for late-onset Alzheimer’s disease (LOAD), the most prevalent dementia, is partially
driven by genetics. To identify LOAD risk loci, we performed a large genome-wide association …

Frontotemporal dementia (FTD) with ubiquitin-immunoreactive neuronal inclusions (both
cytoplasmic and nuclear) of unknown nature has been linked to a chromosome 17q21 region (…

Background Cholinergic deficits are prominent in patients who have dementia associated
with Parkinson's disease. We investigated the effects of the dual cholinesterase inhibitor …