Clinical proton MR spectroscopy in central nervous system disorders
A large body of published work shows that proton (hydrogen 1 [ 1 H]) magnetic resonance (MR)
spectroscopy has evolved from a research tool into a clinical neuroimaging modality. …
spectroscopy has evolved from a research tool into a clinical neuroimaging modality. …
Pathogenesis of multiple sclerosis: insights from molecular and metabolic imaging
The mechanisms underlying the pathogenesis of multiple sclerosis induce the changes that
underpin relapse-associated and progressive disability. Disease mechanisms can be …
underpin relapse-associated and progressive disability. Disease mechanisms can be …
Hypomyelinating leukodystrophies: translational research progress and prospects
PJW Pouwels, A Vanderver, G Bernard… - Annals of …, 2014 - Wiley Online Library
Hypomyelinating leukodystrophies represent a genetically heterogeneous but clinically
overlapping group of heritable disorders. Current management approaches in the care of the …
overlapping group of heritable disorders. Current management approaches in the care of the …
Intracortical Lesions in Multiple Sclerosis: Improved Detection with 3D Double Inversion-Recovery MR Imaging1
JJG Geurts, PJW Pouwels, BMJ Uitdehaag, CH Polman… - Radiology, 2005 - pubs.rsna.org
PURPOSE: To prospectively compare the depiction of intracortical lesions by using
multislab three-dimensional (3D) double inversion-recovery (DIR), multislab 3D fluid-attenuated …
multislab three-dimensional (3D) double inversion-recovery (DIR), multislab 3D fluid-attenuated …
Regional metabolite concentrations in human brain as determined by quantitative localized proton MRS
PJW Pouwels, J Frahm - Magnetic resonance in medicine, 1998 - Wiley Online Library
The regional distribution of brain metabolites was studied in several cortical white and gray
matter areas, cerebellum, and thalamus of young adults with use of quantitative single‐voxel …
matter areas, cerebellum, and thalamus of young adults with use of quantitative single‐voxel …
Cortical lesions in multiple sclerosis: combined postmortem MR imaging and histopathology
JJG Geurts, L Bö, PJW Pouwels… - American Journal …, 2005 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: Cortical lesions constitute a substantial part of the total
lesion load in multiple sclerosis (MS) brain. They have been related to neuropsychological …
lesion load in multiple sclerosis (MS) brain. They have been related to neuropsychological …
Correlating the alpha rhythm to BOLD using simultaneous EEG/fMRI: inter-subject variability
SI Gonçalves, JC De Munck, PJW Pouwels… - Neuroimage, 2006 - Elsevier
Simultaneous recording of electroencephalogram/functional magnetic resonance images (EEG/fMRI)
was applied to identify blood oxygenation level-dependent (BOLD) changes …
was applied to identify blood oxygenation level-dependent (BOLD) changes …
Regional DTI differences in multiple sclerosis patients
…, HE Hulst, KS Cover, JA Castelijns, PJW Pouwels… - Neuroimage, 2009 - Elsevier
Diffusion tensor imaging (DTI) measures have shown to be sensitive to white matter (WM)
damage in multiple sclerosis (MS), not only inside focal lesions but also in user-defined …
damage in multiple sclerosis (MS), not only inside focal lesions but also in user-defined …
[HTML][HTML] Regional age dependence of human brain metabolites from infancy to adulthood as detected by quantitative localized proton MRS
PJW Pouwels, K Brockmann, B Kruse, B Wilken… - Pediatric …, 1999 - nature.com
Regional changes of metabolite concentrations during human brain development were
assessed by quantitative localized proton magnetic resonance spectroscopy in vivo. Apart from …
assessed by quantitative localized proton magnetic resonance spectroscopy in vivo. Apart from …
Cortical atrophy patterns in multiple sclerosis are non-random and clinically relevant
…, BMJ Uitdehaag, F Barkhof, H Vrenken, PJW Pouwels - Brain, 2016 - academic.oup.com
See Chard and Miller (doi: 10.1093/brain/awv354 ) for a scientific commentary on this article
. Grey matter atrophy is common in multiple sclerosis. However, in contrast with other …
. Grey matter atrophy is common in multiple sclerosis. However, in contrast with other …