Purpose The extent of the hemodynamic and metabolic impairments in adult patients with
moyamoya disease is still controversial. The aim of the present study was to evaluate the …

BACKGROUND AND PURPOSE: Alzheimer disease (AD) and vascular dementia (VaD) are
the two major diseases that cause dementia, and early diagnosis is important. Single …

Background and Purpose— Patients with carotid occlusive disease and stage 2 cerebral
hemodynamic failure, characterized by an increased oxygen extraction fraction (OEF) as …

Cerebral metabolic rate of oxygen (CMRO 2 ) can be assessed quantitatively using 15 O 2
and positron emission tomography. Determining the arterial input function is considered …

Background: In vascular dementia (VaD), assessment of cerebral blood flow by single photon
emission computed tomography (CBF SPECT) has been used to detect a patchy decrease …

Insufficient delivery of oxygen to tissue is the central core of ischemia. A large number of
observations in rodents revealed that compensatory responses against ischemia occurs at …

Introduction and Purpose: For efficient development of novel therapeutics in stroke, it is
expected to use a non-human primate stroke model that has a similarity in pathophysiology, as …

Methods We studied 13 patients with chronic ipsilateral MCA occlusion (9 symptomatic and
4 asymptomatic; 7 men and 6 women; mean age 57. 6±11.3 years) who underwent a …

Background The measurement of cerebral blood flow (CBF) by means of single photon
emission computed tomography (SPECT) is a complimentary method to diagnose a brain death. …

It has been believed that direct and accurate assessment of local CMRO2 and CBF is
feasible using 15O-labeled oxygen and PET in vivo. This is true, provided that the local …