Tissue iron can promote oxidative damage. Brain iron increases with age and is abnormally
elevated early in the disease process in several neurodegenerative disorders, including …

Background: Neuropsychiatric disturbances are common in mild cognitive impairment (MCI).
Depression and apathy may identify a subset of MCI subjects at higher risk of progression …

Background Imaging and postmortem studies provide converging evidence that, beginning
in adolescence, gray matter volume declines linearly until old age, while cerebrospinal fluid …

Human and non-human primate data suggest that the structural integrity of myelin sheaths
deteriorates during normal aging, especially in the late-myelinating association regions and …

… Tishler a c e , Po H. Lu a c , Pablo Villablanca f , Lori L. Altshuler c d , Michele Carter a , …
0.5 T), and the two scans were done within 1 h of each other using the same imaging protocol. …

A recently identified variant within the fat mass and obesity-associated (FTO) gene is carried
by 46% of Western Europeans and is associated with an ~1.2 kg higher weight, on average, …

The ε4 allele of the apolipoprotein E (APOE) gene is the major genetic risk factor for
Alzheimer’s disease (AD), but limited work has suggested that APOE genotype may modulate …

OBJECTIVE: Myelination of the human brain results in roughly quadratic trajectories of myelin
content and integrity, reaching a maximum in mid-life and then declining in older age. This …

Background Postmortem and in vivo imaging data support the hypothesis that premature
myelin breakdown and subsequent homeostatic remyelination attempts with increased …

Regions of the temporal and parietal lobes are particularly damaged in Alzheimer's disease
(AD), and this leads to a predictable pattern of brain atrophy. In vivo quantification of …