Pericytes play a key role in the development of cerebral microcirculation. The exact role of
pericytes in the neurovascular unit in the adult brain and during brain aging remains, however…

Human apolipoprotein E has three isoforms: APOE2, APOE3 and APOE4 1 . APOE4 is a
major genetic risk factor for Alzheimer’s disease 2 , 3 and is associated with Down’s syndrome …

Vascular dysfunction has a critical role in Alzheimer’s disease (AD). Recent data from brain
imaging studies in humans and animal models suggest that cerebrovascular dysfunction …

Pericytes are uniquely positioned within the neurovascular unit to serve as vital integrators,
coordinators and effectors of many neurovascular functions, including angiogenesis, blood-…

Achieving sufficient delivery across the blood–brain barrier is a key challenge in the development
of drugs to treat central nervous system (CNS) disorders. This is particularly the case …

… Author links open overlay panel KJ Åström a , RD Bell b … In Bell and Åström (1996) we
added drum dynamics as a fourth-order model. The model in this paper is a refined version of that …

Amyloid β-peptide (Aβ) clearance from the central nervous system (CNS) maintains its low
levels in brain. In Alzheimer's disease, Aβ accumulates in brain possibly because of its faulty …

The main receptors for amyloid-beta peptide (Aβ) transport across the blood-brain barrier (BBB)
from brain to blood and blood to brain are low-density lipoprotein receptor related protein…

Pericytes are cells in the blood–brain barrier that degenerate in Alzheimer’s disease (AD), a
neurological disorder associated with neurovascular dysfunction, abnormal elevation of …

In Alzheimer disease (AD), amyloid β peptide (Aβ) accumulates in plaques in the brain.
Receptor for advanced glycation end products (RAGE) mediates Aβ-induced perturbations in …