New technologies for imaging molecules, particularly optical technologies, are increasingly
being used to understand the complexity, diversity and in vivo behaviour of cancers. 'Omic' …

The term molecular imaging can be broadly defined as the in vivo characterization and
measurement of biologic processes at the cellular and molecular level. In contradistinction to “…

Optical sensing of specific molecular targets and pathways deep inside living mice has
become possible as a result of a number of advances. These include design of biocompatible …

Somatic cell nuclear transfer and transcription-factor-based reprogramming revert adult
cells to an embryonic state, and yield pluripotent stem cells that can generate all tissues. …

A current paradigm states that monocytes circulate freely and patrol blood vessels but
differentiate irreversibly into dendritic cells (DCs) or macrophages upon tissue entry. Here we …

Tumor maintenance relies on continued activity of driver oncogenes, although their rate-limiting
role is highly context dependent. Oncogenic Kras mutation is the signature event in …

Figure 1. Getting the right image.(A) The NIR window is ideally suited for in vivo imaging
because of minimal light absorption by hemoglobin (< 650 nm) and water (> 900 nm).(B) …

Somatic mutations that activate phosphoinositide 3-kinase (PI3K) have been identified in the
p110-α catalytic subunit (encoded by PIK3CA) 1 . They are most frequently observed in two …

Background Accurate detection of lymph-node metastases in prostate cancer is an essential
component of the approach to treatment. We investigated whether highly lymphotropic …

… Reynolds Cardiovascular Clinical Research Center grant on Atherosclerosis at Harvard
Medical School (to R. Weissleder and P. Libby). FK Swirski was supported by a post-doctoral …