Alexander disease (AD) in its typical form is an infantile lethal leucodystrophy, characterized
pathologically by Rosenthal fibre accumulation. Following the identification of glial fibrillary …

Ataxia, a neurological sign characterized by the incoordination of voluntary movements, is
the most prominent manifestation of cerebellar disease. The cardinal features of cerebellar …

Objective: To identify factors that determine disease severity and clinical phenotype of the
most common spinocerebellar ataxias (SCAs), we studied 526 patients with SCA1, SCA2, …

Objective: To obtain quantitative data on the progression of the most common spinocerebellar
ataxias (SCAs) and identify factors that influence their progression, we initiated the …

Objective: To determine the longitudinal metric properties of recently developed clinical
assessment tools in spinocerebellar ataxia (SCA). Methods: A subset of 171 patients from the …

To evaluate the efficacy of treatments in spinocerebellar ataxias (SCAs), appropriate clinical
scales are required. This study evaluated metric properties of the International Cooperative …

… Fancellu: Stock Ownership in medically related fields: none. Consultancies: none.
Advisory … R. Fancellu received research support from the EUROSCA grant LSHM-CT-2004-503304. …

Objective: To evaluate the usefulness of functional measures in patients with spinocerebellar
ataxia (SCA). Methods: We assessed three functional measures—8 m walking time (8MW), …

Objectives – While clinical hypothyroidism is associated with frank neuropsychological and
affective alterations and is considered one of the causes of reversible dementia, the …

… Roberto Fancellu , Roberto Fancellu … We used the Student t-test for unpaired data and
the Pearson correlation coefficient (r). Minimum statistical significance was set at P <0.05. …