The immune system has developed a variety of mecharmisms for sensing the presence of
invading microorganisms, which must be accomplished in the face of special topological …

… Using both kinetic and pronase-stripping analyses, Lucas and Germain then found that
this result, and much of the confusing lineage data, could be explained by the previous …

… Bikoff, R. Germain, unpublished observations). This indicates that peptide does not play
an essential role in the formation or transport rate of unstable class II dimers. The absence of …

… Affy R package. Principal component analysis was performed using arrayQualityMetrics R
… Differential expression analysis was performed between any two subsets using limma R …

Barrier epithelial cells and airway dendritic cells (DCs) make up the first line of defense
against inhaled substances such as house dust mite (HDM) allergen and endotoxin (…

We have previously demonstrated that the inhibitory effects of IL-10 on ConA-induced T cell
proliferation or IL-2 production by resting murine T cells were only observed when …

This paper gives an overview of the BlueGene/L Supercomputer. This is a jointly funded
research partnership between IBM and the Lawrence Livermore National Laboratory as part of …

Mutations in the gene encoding NLRP3 cause a spectrum of autoinflammatory diseases
known as cryopyrin-associated periodic syndromes (CAPS) 1 . NLRP3 is a key component of …

After entry into lymph nodes (LNs), B cells migrate to follicles, whereas T cells remain in the
paracortex, with each lymphocyte type showing apparently random migration within these …

The early induction of interleukin (IL)-12 is a critical event in determining the development of
both innate resistance and adaptive immunity to many intracellular pathogens. Previous in …