The primary motor cortex (M1) is essential for voluntary fine-motor control and is functionally
conserved across mammals 1 . Here, using high-throughput transcriptomic and epigenomic …

There is robust evidence that sex (biological) and gender (behavioral/social) differences
influence hearing loss risk and outcomes. These differences are noted for animals and humans…

… Research in the Hertzano laboratory is supported by funding from the US National Institutes
of Health (grants R01DC013817 and R01DC019370), the US Department of Defense (grant …

Objective: To critically review and evaluate the proposed mechanisms and documented results
of the therapeutics currently in active clinical drug trials for the treatment of sensorineural …

Mammalian hearing requires the development of the organ of Corti, a sensory epithelium
comprising unique cell types. The limited number of each of these cell types, combined with …

Normal vision in Drosophila requires NINAC, a class III myosin. Class III myosins are hybrid
motor-signaling molecules, with an N-terminal kinase domain, highly conserved head and …

Pou4f3 (Brn3.1, Brn3c) is a class IV POU domain transcription factor that has a central function
in the development of all hair cells in the human and mouse inner ear sensory epithelia. A …

Single-cell transcriptomics can provide quantitative molecular signatures for large, unbiased
samples of the diverse cell types in the brain 1 , 2 – 3 . With the proliferation of multi-omics …

… We thank R. Marini for technical assistance. This work was funded by the Hearing Restoration
Project (RH); R01-DC013817 and R01-DC019370 (RH); R24- 96MH114815 (RH and OW)…

Noise-induced hearing loss (NIHL) results from a complex interplay of damage to the
sensory cells of the inner ear, dysfunction of its lateral wall, axonal retraction of type 1C spiral …