Copper is an essential cofactor for all organisms, and yet it becomes toxic if concentrations
exceed a threshold maintained by evolutionarily conserved homeostatic mechanisms. How …

Abdominal pain is one of the most frequent reasons that elderly people visit the emergency
department (ED). In this article, we review the deadliest causes of abdominal pain in this …

A large collaborative effort has yielded a comprehensive study of the phylogeny and a new
subfamilial classification of the grass family (Poaceae/Gramineae). The study was conducted …

We have identified a new role for the matrix enzyme lysyl oxidase–like-2 (LOXL2) in the
creation and maintenance of the pathologic microenvironment of cancer and fibrotic disease. …

Anticancer uses of non-oncology drugs have occasionally been found, but such discoveries
have been serendipitous. We sought to create a public resource containing the growth-…

A phylogenetic analysis of the Solanaceae based on chloroplast DNA variation is presented.
Restriction site maps were determined for 79 species (52 genera) for 11 restriction enzymes…

A genetic-epidemiologic study was undertaken of a white Colorado population of 207 patients
who had a myocardial infarction before age 55 years. Nineteen independent variables …

II In his illuminating book on The Nature of Thermodynamics, Bridgeman (1941) points out
an intrinsic contradiction between the concepts of physical and biological evolution. In his …

Drugs abused by humans are thought to activate areas in the ventral striatum of the brain
that engage the organism in important adaptive behaviors, such as eating. In support of this, …

Recent genetic, cytogenetic, and clinical findings of the Ullrich-Noonan syndrome have been
reviewed in the context of a personal series of 81 patients, the majority of whom were found …