CD1d-restricted natural killer T (NKT) cells are innate-like lymphocytes that express a conserved
T-cell receptor and contribute to host defence against various microbial pathogens 1 , 2 …

Glycolipid presentation by CD1 proteins has emerged as an important aspect of antigen
recognition, and presentation of α-glycosylceramides by CD1d to natural killer T cells has …

CD1d presentation of α-galactosyl ceramides to natural killer T cells has been a focal point
of the study of regulatory T cells. KRN7000, an α-galactosyl ceramide originally generated …

A chemoenzymatic platform for the synthesis of S‐adenosyl‐L‐methionine (SAM) analogues
compatible with downstream SAM‐utilizing enzymes is reported. Forty‐four non‐native S/Se…

Sugars appended to pharmaceutically important natural products influence key pharmacological
properties and/or molecular mechanism of action.[1] However, studies designed to …

Purpose: Primary brain tumors are the leading cause of cancer death in children. Our
purpose is (a) to assess the contribution of the DNA repair protein O 6 -methylguanine-DNA …

α-Galactosylceramides are potent stimulators of human T cells. Stimulation occurs through
binding of the glycolipids by CD1d, presentation to T cells, and formation of a CD1d−glycolipid…

A comprehensive two-phase "hot spot" saturation mutagenesis strategy for the rapid evolution
of glycosyltransferase (GT) specificity for nonnatural acceptors is described. Specifically, …

Methionine adenosyltransferase ( MAT ) is a family of enzymes that utilizes ATP and
methionine to produce S‐adenosylmethionine (AdoMet), the most crucial methyl donor in the …

Glycosyltransferases are useful synthetic catalysts for generating natural products with
sugar moieties. Although several natural product glycosyltransferase structures have been …