Huntington disease is devastating to patients and their families—with autosomal dominant
inheritance, onset typically in the prime of adult life, progressive course, and a combination of …

Huntington disease (HD) can be seen as a model neurodegenerative disorder, in that it is
caused by a single genetic mutation and is amenable to predictive genetic testing, with …

Hippocampal atrophy rates are useful in both diagnosing and tracking Alzheimer's disease (AD).
However, cohorts and methods used to determine such rates are heterogeneous, …

To be diagnostically useful, structural MRI must reliably distinguish Alzheimer's disease (AD)
from normal aging in individual scans. Recent advances in statistical learning theory have …

Objective To investigate the effect of age on global and regional brain volumes and rates of
atrophy, and to compare directly results based on cross-sectional and longitudinal data. …

Background Huntington's disease (HD) is an autosomal dominant, fully penetrant,
neurodegenerative disease that most commonly affects adults in mid-life. Our aim was to identify …

Volumetric magnetic resonance imaging analyses of 30 subjects were undertaken to quantify
the global and temporal lobe atrophy in semantic dementia and Alzheimer's disease. …

Alzheimer's disease (AD) is characterized by progressive cerebral atrophy, which may be
assessed by using volumetric MRI. We describe a voxel-based analysis of nonlinear-…

Background TRACK-HD is a multinational prospective observational study of Huntington's
disease (HD) that examines clinical and biological findings of disease progression in …

Background TRACK-HD is a prospective observational study of Huntington's disease (HD)
that examines disease progression in premanifest individuals carrying the mutant HTT gene …