Enhanced glutathione PEGylated liposomal brain delivery of an anti-amyloid single domain antibody fragment in a mouse model for Alzheimer's disease

…, ME de Backer, J Rip, RJA Nabuurs… - Journal of Controlled …, 2015 - Elsevier
Abstract Treatment of neurodegenerative disorders such as Alzheimer's disease is hampered
by the blood–brain barrier (BBB). This tight cerebral vascular endothelium regulates …

Cortical iron reflects severity of Alzheimer's disease

…, M Bulk, SG van Duinen, RJA Nabuurs… - Journal of …, 2017 - content.iospress.com
Abnormal iron distribution in the isocortex is increasingly recognized as an in vivo marker
for Alzheimer’s disease (AD). However, the contribution of iron accumulation to the AD …

Brain histopathology in patients with systemic lupus erythematosus: identification of lesions associated with clinical neuropsychiatric lupus syndromes and the role of …

D Cohen, EC Rijnink, RJA Nabuurs… - …, 2016 - academic.oup.com
Objectives. Neuropsychiatric (NP) involvement is a poorly understood manifestation of SLE.
We studied post-mortem histopathology in relation to clinical NPSLE syndromes and …

Postmortem MRI and histology demonstrate differential iron accumulation and cortical myelin organization in early-and late-onset Alzheimer's disease

M Bulk, WM Abdelmoula, RJA Nabuurs… - Neurobiology of …, 2018 - Elsevier
Previous MRI studies reported cortical iron accumulation in early-onset (EOAD) compared
to late-onset (LOAD) Alzheimer disease patients. However, the pattern and origin of iron …

[HTML][HTML] Inter-rater agreement in glioma segmentations on longitudinal MRI

…, M Smits, N Verburg, EJ Hendriks, RJA Nabuurs… - NeuroImage: Clinical, 2019 - Elsevier
Background Tumor segmentation of glioma on MRI is a technique to monitor, quantify and
report disease progression. Manual MRI segmentation is the gold standard but very labor …

Potential role of antimicrobial peptides in the early onset of Alzheimer's disease

MM Welling, RJA Nabuurs, L van der Weerd - Alzheimer's & Dementia, 2015 - Elsevier
Cerebral aggregation of amyloid-β (Aβ) is thought to play a major role in the etiology of
Alzheimer's disease. Environmental influences, including chronic bacterial or viral infections, are …

Functional and structural diversification of the Anguimorpha lizard venom system

…, K Winter, JA Norman, K Roelants, RJA Nabuurs… - Molecular & Cellular …, 2010 - ASBMB
Venom has only been recently discovered to be a basal trait of the Anguimorpha lizards.
Consequently, very little is known about the timings of toxin recruitment events, venom protein …

Comparison of histological techniques to visualize iron in paraffin-embedded brain tissue of patients with Alzheimer's disease

S van Duijn, RJA Nabuurs… - … of Histochemistry & …, 2013 - journals.sagepub.com
Better knowledge of the distribution of iron in the brains of Alzheimer’s disease (AD) patients
may facilitate the development of an in vivo magnetic resonance (MR) marker for AD and …

Cerebral amyloidosis: postmortem detection with human 7.0-T MR imaging system

S van Rooden, MLC Maat-Schieman, RJA Nabuurs… - Radiology, 2009 - pubs.rsna.org
Purpose To explore the ability of whole-body 7.0-T magnetic resonance (MR) imaging to
depict differences in aspects of the cerebral cortex of postmortem human brain specimens with …

MRI artifacts in human brain tissue after prolonged formalin storage

S van Duijn, RJA Nabuurs… - Magnetic resonance …, 2011 - Wiley Online Library
… van Duijn and Rob JA Nabuurs contributed equally to this … van Duijn and Rob JA Nabuurs
contributed equally to this work… van Duijn and Rob JA Nabuurs contributed equally to this work…