Background and purpose: Neuromyelitis optica (NMO) or Devic′s disease is a rare
inflammatory and demyelinating autoimmune disorder of the central nervous system (CNS) …

… RQ Hintzen is supported by a grant from the Dutch Society for Research on Multiple Sclerosis.
RAW van Lier is a fellow of the Royal Dutch Academy of Arts and Sciences. We wish to …

(HSCT) as a treatment for severe autoimmune diseases beginning in the early 1990s.
According to multicenter reports, this therapy has been plagued by a high rate of transplant-related …

One of the characteristics of multiple sclerosis is the unpredictable occurrence of exacerbations
and remissions. These fluctuations in disease activity are related to alterations in (auto‐)…

Objectives – Studies demonstrating reduced quality of life and psychological well‐being in
multiple sclerosis (MS) have typically investigated patients within more advanced stages of …

Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS)
characterized by autoimmune-mediated demyelination and neurodegeneration. The CNS of …

Multiple sclerosis lesion activity concurs with the extent of inflammation, demyelination and
axonal suffering. Pro-inflammatory myeloid cells contribute to lesion development, but the self…

The major histocompatibility complex (MHC) region is strongly associated with multiple sclerosis
(MS) susceptibility. HLA-DRB1*15:01 has the strongest effect, and several other alleles …

CD27, a lymphocyte-specific member of the TNF/NGF-R family, is expressed on the majority
of peripheral blood T cells. Activation of T cells via TCR/CD3 induces high CD27 surface …

Dendritic cells are thought to regulate tolerance induction vs immunization by transferring
Ags and peripheral signals to draining lymph nodes (LN). However, whether myelin Ag …