von Hippel-Lindau disease is a heritable multisystem cancer syndrome that is associated with
a germline mutation of the VHL tumour suppressor gene on the short arm of chromosome …

Neurofibromatosis type 2 is an autosomal-dominant multiple neoplasia syndrome that results
from mutations in the NF2 tumour suppressor gene located on chromosome 22q. It has a …

The brain is in many ways an immunologically and pharmacologically privileged site. The
blood–brain barrier (BBB) of the cerebrovascular endothelium and its participation in the …

Object. The goals of this study were to define the natural history and growth pattern of
hemangioblastomas of the central nervous system (CNS) that are associated with von Hippel—…

Object The management of odontoid fractures remains controversial. Only direct anterior
screw fixation provides immediate stabilization of the spine and may preserve normal C1–2 …

Object. Although recent studies have shown that convection can be used to distribute
macromolecules within the central nervous system (CNS) in a homogeneous, targeted fashion …

… ∂ r ς rr ∂ r d θ d z d r Equation B2 … EB5, we immediately write expressions for ς rr and
ς θθ , recalling that e zz = 0 ς rr = ( 2 G + λ ) e rr + λ e θ θ Equation B6a …

Object. Von Hippel—Lindau (VHL) disease is an autosomal-dominant disorder frequently
associated with hemangioblastomas of the spinal cord. Because of the slow progression, …

… Nduom EK, Walbridge S, Lonser RR: Comparison of pulsed versus continuous convective
flow for central nervous system tissue perfusion. Laboratory investigation. J Neurosurg 117:…

Object In the course of their lives most patients with von Hippel–Lindau (VHL) disease
require treatment for several symptom-producing hemangioblastomas of the cerebellum, …