BACKGROUND Liquid biopsies that are based on analysis of cell-free DNA from plasma
offer diagnostic information that is otherwise accessible conventionally through invasive …

Over the past 40 years, much effort has been spent on developing non-invasive prenatal
diagnostic methods. Since 1997, the progress of this field has been accelerated by the …

Assay of Circulating Cell-Free DNA in Pregnancy Advances in DNA sequencing have
facilitated a change in the method used to screen for fetal chromosome trisomies. This …

Chromosomal aneuploidy is the major reason why couples opt for prenatal diagnosis.
Current methods for definitive diagnosis rely on invasive procedures, such as chorionic villus …

Cell-free fetal DNA is present in the plasma of pregnant women. It consists of short DNA
fragments among primarily maternally derived DNA fragments. We sequenced a maternal …

Background: The discovery of circulating fetal nucleic acids in maternal plasma has opened
up new possibilities for noninvasive prenatal diagnosis. MicroRNAs (miRNAs), a class of …

… 14 Lo YMD, Chiu RWK. Prenatal diagnosis: progress through plasma nucleic acids. Nat …
20 Chiu RWK, Cantor CR, Lo YMD. Non-invasive prenatal diagnosis by single molecule …

BACKGROUND:: The effect of corticosteroid treatment on the viral load of Severe Acute
Respiratory Syndrome (SARS) patients is unknown. OBJECTIVE:: To compare the plasma SARS-…

Background: Despite current interest in the biology and diagnostic applications of cell-free
DNA in plasma and serum, the cellular origin of this DNA is poorly understood. We used a sex-…

The analysis of tumor-derived circulating cell-free DNA opens up new possibilities for
performing liquid biopsies for the assessment of solid tumors. Although its clinical potential has …