Therapeutic strategies to protect the ischemic myocardium have been studied extensively.
Reperfusion is the definitive treatment for acute coronary syndromes, especially acute …

Postpartum cardiomyopathy (PPCM) is a disease of unknown etiology and exposes women
to high risk of mortality after delivery. Here, we show that female mice with a cardiomyocyte-…

Changes in plasma nitrite concentration in the human forearm circulation have recently
been shown to reflect acute changes in endothelial nitric oxide synthase (eNOS)-activity. …

The synthesis of nitric oxide (NO) in the circulation has been attributed exclusively to the
vascular endothelium. Red blood cells (RBCs) have been demonstrated to carry a …

Pre-, post-, and remote conditioning of the myocardium are well described adaptive
responses that markedly enhance the ability of the heart to withstand a prolonged ischemia/…

Ischaemic postconditioning (brief periods of ischaemia alternating with brief periods of
reflow applied at the onset of reperfusion following sustained ischaemia) effectively reduces …

Administration of nitric oxide (NO), NO donors or drugs that enhance NO realease (statins,
calcium antagonists, ACE-inhibitors, dexamethasone) prior to ischemia protects the …

Many treatments have been identified that confer robust cardioprotection in experimental
animal models of acute ischemia and reperfusion injury. However, translation of these …

Over the past 2 to 3 decades, several phenomena have been identified that provide
powerful protection against myocardial infarction and other sequelae of ischemia/reperfusion1: …

TNFα is crucially involved in the pathogenesis and progression of atherosclerosis, myocardial
ischemia/reperfusion injury and heart failure. The formation and release of TNFα and its …