Basal ganglia disorders are a heterogeneous group of clinical syndromes with a common
anatomic locus within the basal ganglia. To account for the variety of clinical manifestations …

Huntington disease (HD) is characterized by the loss of striatal projection neurons, which
constitute the vast majority of striatal neurons. To determine whether there is differential loss …

The concept of excitotoxicity, neuronal death produced by overstimulation of excitatory
ammo acid receptors, has become a popular way of explaining the pathogenesis of neuronal …

Seeking antemortem markers to distinguish Dementia with Lewy bodies (DLB) and Alzheimer's
disease (AD), we examined brain glucose metabolism of DLB and AD. Eleven DLB …

Mice representing precise genetic replicas of Huntington’s disease (HD) were made using
gene targeting to replace the short CAG repeat of the mouse Huntington’s disease gene …

Although Parkinson disease (PD) is viewed traditionally as a motor syndrome secondary to
nigrostriatal dopaminergic denervation, recent studies emphasize non-motor features. Non-…

We have used RNA in situ hybridization to study the regional expression of the Huntington's
disease gene (HD) and its rat homologue in brain and selected nonneural tissues. The HD …

Tourette syndrome (TS) is a developmentally regulated neurobehavioral disorder
characterized by involuntary, stereotyped, repetitive movements. Recent anatomical and …

Parkinson’s disease (PD) is one of the world’s fastest growing neurological disorders. Much
is unknown about PD-associated economic burdens in the United States (US) and other high…

The mutations responsible for several human neurodegenerative disorders are expansions
of translated CAG repeats beyond a normal size range. To address the role of repeat context…