Estrogen receptor (ER) binds to estrogen response elements in target genes and recruits a
coactivator complex of CBP-pl60 that mediates stimulation of transcription. ER also activates …

We find that tamoxifen is a potent activator of estrogen receptor (ER)- mediated induction of
promoters regulated by AP-1 sites including the human collagenase gene promoter and …

Induction of cyclin D1 gene transcription by estrogen receptor α (ERα) plays an important role
in estrogen-mediated proliferation. There is no classical estrogen response element in the …

The activity of the AF-2 transcriptional activation function of nuclear receptors (NR) is
mediated by the partially homologous transcriptional coactivators, glucocorticoid receptor …

It is now well established that estrogens can influence a panoply of physiological and
behavioral functions. In many instances, the effects of estrogens are mediated by the ‘classical’ …

… More recently, we have found that 3β-Diol treatment stimulates CRH expression rapidly; it
increases mRNA levels between 1 and 5 mins of exposure (Stacey and Uht, unpublished data)…

Estrogens and glucocorticoids often act in opposition to regulate physiological responses.
We investigated whether this might reflect the opposing actions of hormone-bound receptors …

The hypothalamic-pituitary-adrenal axis regulates mammalian stress responses by secreting
glucocorticoids. The magnitude of the response is in part determined by gender, for in …

… *Address all correspondence and requests for reprints to: Rosalie M. Uht, MD, Ph.D.,
Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, PO …

A 13-month-old boy developed eosinophilic meningoencephalitis, retinitis, and a protracted
encephalopathy with severe residual deficits. The initial MR examination revealed diffuse …