Drug discovery and development are hampered by high failure rates attributed to the reliance
on non-human animal models employed during safety and efficacy testing. A fundamental …

Gelatinase A (MMP‐2), a matrix metalloproteinase (MMP) involved in tumor invasion and
angiogenesis, is secreted as an inactive zymogen (proMMP‐2) and activated by proteolytic …

… Marcus on their excellent presentation of their experience with the management of the
pancreatic stump during the Whipple operation. I hate to admit it, and I'm a little humiliated to do so…

Drug discovery and development to date has relied on animal models, which are useful but
are often expensive, slow, and fail to mimic human physiology. The discovery of human …

von Willebrand factor (vWF), a glycoprotein produced uniquely by endothelial cells and
megakaryocytes, is routinely used to identify vessels in tissue sections. Vessel density in tumor …

Fewer than 1% of patients with renal cell carcinoma are reported to experience spontaneous
regression of metastatic lesions after nephrectomy. We report on 4 of 91 patients (4.4%) …

Background & Aims Patients with hepatitis C virus (HCV) infection with psychiatric disorders
and/or substance abuse face significant barriers to antiviral treatment. New strategies are …

Human organ-on-a-chip systems for drug screening have evolved as feasible alternatives to
animal models, which are unreliable, expensive, and at times erroneous. While chips …

A pilot study was undertaken to test the safety and establish the side effect profile of recombinant
human interferon-β lb (Betaseron, Berlex Laboratories, Richmond, CA), in patients with …

Background Patients who present with stage IV gastric cancer are not commonly managed
with surgical resection as effective palliation can usually be accomplished with systemic …