Phase I clinical evaluation of a new iron oxide MR contrast agent
SJ McLachlan, MR Morris, MA Lucas… - Journal of Magnetic …, 1994 - Wiley Online Library
The safety and magnetic resonance (MR) imaging potential of BMS 180549, a new
superparamagnetic iron oxide contrast agent, were evaluated in a phase I, open‐label, placebo‐…
superparamagnetic iron oxide contrast agent, were evaluated in a phase I, open‐label, placebo‐…
Initial clinical experience with dextran-coated superparamagnetic iron oxide for detection of lymph node metastases in patients with head and neck cancer.
PURPOSE: To investigate the efficacy of magnetic resonance (MR) imaging with dextran-coated
superparamagnetic iron oxide in the differentiation of metastatic and benign nodes in …
superparamagnetic iron oxide in the differentiation of metastatic and benign nodes in …
Myoglobin: cytochrome b5 interactions and the kinetic mechanism of metmyoglobin reductase.
DJ Livingston, SJ McLachlan, GN La Mar… - Journal of Biological …, 1985 - ASBMB
Metmyoglobin (metMb) reduction by metMb reductase from heart muscle requires cytochrome
b5 as electron-transfer mediator. The existence of a metMb-ferrous cytochrome b5 …
b5 as electron-transfer mediator. The existence of a metMb-ferrous cytochrome b5 …
MR angiography with an ultrasmall superparamagnetic iron oxide blood pool agent
…, JH Maki, FLM London, SJ McLachlan - Journal of Magnetic …, 1997 - Wiley Online Library
The purpose of the study was to investigate the use of a dextran‐coated ultrasmall
superparamagnetic iron oxide (USPIO) as a blood pool contrast agent for thoracic and abdominal …
superparamagnetic iron oxide (USPIO) as a blood pool contrast agent for thoracic and abdominal …
Diagnosis of carotid artery stenosis: comparison of 2DFT time-of-flight MR angiography with contrast angiography in 50 patients.
…, RS Pinto, TS Riles, SJ McLachlan… - American journal …, 1991 - Am Soc Neuroradiology
Fifty patients underwent 2DFT time-of-flight MR angiography and intraarterial contrast
angiography for evaluation of possible carotid atherosclerotic disease. The MR angiography …
angiography for evaluation of possible carotid atherosclerotic disease. The MR angiography …
AMI-227-enhanced MR lymphography: usefulness for differentiating reactive from tumor-bearing lymph nodes.
P Vassallo, C Matei, WD Heston, SJ McLachlan… - Radiology, 1994 - pubs.rsna.org
PURPOSE: To determine the value of magnetic resonance (MR) lymphography enhanced
with AMI-227, a superparamagnetic reticuloendothelial-system-specific contrast agent, to …
with AMI-227, a superparamagnetic reticuloendothelial-system-specific contrast agent, to …
Pharmacokinetic behavior of gadoteridol injection
SJ McLACHLAN, S EATON… - Investigative …, 1992 - journals.lww.com
McLachian SJ, Eaton S, De Simone DN. Pharmacokinetic behavior of gadoteridol injection.
Invest Radiol 1992; 27: S12–S15. RATIONALE AND OBJECTIVES. To assess the safety and …
Invest Radiol 1992; 27: S12–S15. RATIONALE AND OBJECTIVES. To assess the safety and …
1H-NMR assignments and the dynamics of interconversion of the isomeric forms of cytochrome b5 in solution
SJ McLachlan, GN La Mar, PD Burns, KM Smith… - … et Biophysica Acta (BBA …, 1986 - Elsevier
Cytochrome b 5 reconstituted with specifically deuterated hemins has led to the assignment
of the resolved 6,7β-propionate protons and heme meso protons. Freshly reconstituted …
of the resolved 6,7β-propionate protons and heme meso protons. Freshly reconstituted …
Characterization of reactive versus tumor-bearing lymph nodes with interstitial magnetic resonance lymphography in an animal model
…, C Matei, WDW Heston, SJ McLACHLAN… - Investigative …, 1995 - journals.lww.com
RATIONALE AND OBJECTIVES To determine if magnetic resonance lymphography performed
with subcutaneously administered AMI-227, a nanoparticulate iron oxide contrast agent, …
with subcutaneously administered AMI-227, a nanoparticulate iron oxide contrast agent, …
One-and two-dimensional nuclear Overhauser effect studies of the eletronic/molecular structure of the heme cavity of ferricytochrome b5
SJ McLachlan, GN La Mar, KB Lee - Biochimica et Biophysica Acta (BBA) …, 1988 - Elsevier
A nuclear Overhauser effect, NOE, study of solubilized native bovine ferricytochrome b 5 has
provided the complete assignment of the heme resonances as well as those of the majority …
provided the complete assignment of the heme resonances as well as those of the majority …
