… been suggested that RLS is a highly … is hampered by possible intrafamilial, allelic, and
nonallelic heterogeneity. One important prerequisite for future successful genetic studies in RLS is …

… Whether or not the level increase is of central origin is unknown, as histamine is highly
concentrated in mast cells and blood.In rats, we recently found that CSF histamine contents were …

… Wild-type protein fused to GFP is processed into mature secretory vesicles and is not …
Mutant protein fused to GFP is retained in a tubular network overlapping with syntaxin-17, and is …

… Narcolepsy is a chronic disease commonly diagnosed in middle adulthood. However, the …
The aim of the review is to stress some specific features of the clinical picture in children, to …

… is a genuine disease entity. Measuring CSF hypocretin-1 is a definitive diagnostic test,
provided that it is … It may be most useful in cases with cataplexy and when the MSLT is difficult to …

… cases with hypocretin deficiency is approximate, as this … is in doubt, either because the
clinical picture is not completely clear or because the clinical picture is clear but the subject is …

Narcolepsy with cataplexy, characterized by sleepiness and rapid onset into REM sleep, affects
1 in 2,000 individuals 1 , 2 . Narcolepsy was first shown to be tightly associated with HLA-…

… In humans, narcolepsy is rarely due to hypocretin mutations, but this system is deficient in …
We conclude that the hypocretin ligand is deficient in most cases of human narcolepsy, …

Objective: To examine the specificity of low CSF hypocretin-1 levels in narcolepsy and
explore the potential role of hypocretins in other neurologic disorders. Methods: A method to …

Study Objectives: Narcolepsy-cataplexy has long been thought to have an autoimmune
origin. Although susceptibility to narcolepsy, like many autoimmune conditions, is largely …