Astrocytic tumors account for 42% of childhood brain tumors, arising in all anatomical regions
and associated with neurofibromatosis type 1 (NF1) in 15%. Anatomical site determines …

Purpose Recurrent glioblastoma multiforme (GBM) is incurable with current therapies. Biallelic
mismatch repair deficiency (bMMRD) is a highly penetrant childhood cancer syndrome …

… Immunohistochemical stains showed strong s-100 protein and glial fibrillary acidic protein
(GFAP) reactivity in the glial element. Epithelial membrane antigen (EMA) staining was scant …

We present an extensive assessment of mutation burden through sequencing analysis of >81,000
tumors from pediatric and adult patients, including tumors with hypermutation caused …

DNA replication−associated mutations are repaired by two components: polymerase
proofreading and mismatch repair. The mutation consequences of disruption to both repair …

… Interest in aflatoxins rose in 1960’s when this class of mycotoxins was identified for the first
time after an outbreak of acute feed-related mycotoxicosis occurred in England [1]. Since then…

… ature may be confusing in seeing the overall picture of BST’s as most published data is
on children who were operated on. This surgical bias tends to overestimate the relative …

Adenosine-to-inosine (A-to-I) RNA editing was recently shown to be abundant in the human
transcriptome, affecting thousands of genes. Employing a bioinformatic approach, we …

The present study describes the characterization of an experimental model of closed head
injury (CHI) in the mouse. This model is a modification of a setup described and used …

OBJECTIVE: To develop a model to predict the probability of endoscopic third ventriculostomy
(ETV) success in the treatment for hydrocephalus on the basis of a child's individual …