User profiles for S. Mani

Sendurai A. Mani

- Verified email at brown.edu - Cited by 32913

Sudhagar Mani

- Verified email at engr.uga.edu - Cited by 9307

Subramani Mani

- Verified email at salud.unm.edu - Cited by 5561

Guidelines and definitions for research on epithelial–mesenchymal transition

…, H Levine, J Liu, GD Longmore, SA Mani… - … reviews Molecular cell …, 2020 - nature.com
Epithelial–mesenchymal transition (EMT) encompasses dynamic changes in cellular organization
from epithelial to mesenchymal phenotypes, which leads to functional changes in cell …

[HTML][HTML] Wuhan to world: the COVID-19 pandemic

…, L Thakur, S Sati, S Mani, S Asthana… - Frontiers in cellular …, 2021 - frontiersin.org
… The total RNA was extracted from these infected cells and used to clone and sequence the
causative agent(s). Most of sequence reads matched against the lineage B of the genus beta-…

Unexplored therapeutic opportunities in the human genome

…, A Ma'ayan, A Malovannaya, S Mani… - Nature reviews Drug …, 2018 - nature.com
A large proportion of biomedical research and the development of therapeutics is focused
on a small fraction of the human genome. In a strategic effort to map the knowledge gaps …

[HTML][HTML] The epithelial-mesenchymal transition generates cells with properties of stem cells

SA Mani, W Guo, MJ Liao, EN Eaton, A Ayyanan… - Cell, 2008 - cell.com
The epithelial-mesenchymal transition (EMT) is a key developmental program that is often
activated during cancer invasion and metastasis. We here report that the induction of an EMT …

Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota

…, S Cording, G Eberl, A Schlitzer, F Ginhoux, S Mani… - Science, 2015 - science.org
Antibodies targeting CTLA-4 have been successfully used as cancer immunotherapy. We
find that the antitumor effects of CTLA-4 blockade depend on distinct Bacteroides species. In …

[HTML][HTML] Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis

J Yang, SA Mani, JL Donaher, S Ramaswamy… - cell, 2004 - cell.com
Metastasis is a multistep process during which cancer cells disseminate from the site of
primary tumors and establish secondary tumors in distant organs. In a search for key regulators …

Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways

TT Onder, PB Gupta, SA Mani, J Yang, ES Lander… - Cancer research, 2008 - AACR
Loss of the epithelial adhesion molecule E-cadherin is thought to enable metastasis by
disrupting intercellular contacts—an early step in metastatic dissemination. To further investigate …

Mice lacking progesterone receptor exhibit pleiotropic reproductive abnormalities.

JP Lydon, FJ DeMayo, CR Funk, SK Mani… - Genes & …, 1995 - genesdev.cshlp.org
Although progesterone has been recognized as essential for the establishment and maintenance
of pregnancy, this steroid hormone has been recently implicated to have a functional …

Effects of compressive force, particle size and moisture content on mechanical properties of biomass pellets from grasses

S Mani, LG Tabil, S Sokhansanj - Biomass and bioenergy, 2006 - Elsevier
… factors (s×f, s×m) were significant. This may be due to the stiffness of particles and different
elastic properties of wheat straw, which make the particles rigid to compression pressure. The …

Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes

…, JM Rosen, RA Weinberg, SA Mani - Proceedings of the …, 2010 - National Acad Sciences
The epithelial-to-mesenchymal transition (EMT) produces cancer cells that are invasive,
migratory, and exhibit stem cell characteristics, hallmarks of cells that have the potential to …