Guidelines and definitions for research on epithelial–mesenchymal transition
Epithelial–mesenchymal transition (EMT) encompasses dynamic changes in cellular organization
from epithelial to mesenchymal phenotypes, which leads to functional changes in cell …
from epithelial to mesenchymal phenotypes, which leads to functional changes in cell …
[HTML][HTML] Wuhan to world: the COVID-19 pandemic
… The total RNA was extracted from these infected cells and used to clone and sequence the
causative agent(s). Most of sequence reads matched against the lineage B of the genus beta-…
causative agent(s). Most of sequence reads matched against the lineage B of the genus beta-…
Unexplored therapeutic opportunities in the human genome
A large proportion of biomedical research and the development of therapeutics is focused
on a small fraction of the human genome. In a strategic effort to map the knowledge gaps …
on a small fraction of the human genome. In a strategic effort to map the knowledge gaps …
[HTML][HTML] The epithelial-mesenchymal transition generates cells with properties of stem cells
The epithelial-mesenchymal transition (EMT) is a key developmental program that is often
activated during cancer invasion and metastasis. We here report that the induction of an EMT …
activated during cancer invasion and metastasis. We here report that the induction of an EMT …
Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota
…, S Cording, G Eberl, A Schlitzer, F Ginhoux, S Mani… - Science, 2015 - science.org
Antibodies targeting CTLA-4 have been successfully used as cancer immunotherapy. We
find that the antitumor effects of CTLA-4 blockade depend on distinct Bacteroides species. In …
find that the antitumor effects of CTLA-4 blockade depend on distinct Bacteroides species. In …
[HTML][HTML] Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis
J Yang, SA Mani, JL Donaher, S Ramaswamy… - cell, 2004 - cell.com
Metastasis is a multistep process during which cancer cells disseminate from the site of
primary tumors and establish secondary tumors in distant organs. In a search for key regulators …
primary tumors and establish secondary tumors in distant organs. In a search for key regulators …
Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways
Loss of the epithelial adhesion molecule E-cadherin is thought to enable metastasis by
disrupting intercellular contacts—an early step in metastatic dissemination. To further investigate …
disrupting intercellular contacts—an early step in metastatic dissemination. To further investigate …
Mice lacking progesterone receptor exhibit pleiotropic reproductive abnormalities.
JP Lydon, FJ DeMayo, CR Funk, SK Mani… - Genes & …, 1995 - genesdev.cshlp.org
Although progesterone has been recognized as essential for the establishment and maintenance
of pregnancy, this steroid hormone has been recently implicated to have a functional …
of pregnancy, this steroid hormone has been recently implicated to have a functional …
Effects of compressive force, particle size and moisture content on mechanical properties of biomass pellets from grasses
… factors (s×f, s×m) were significant. This may be due to the stiffness of particles and different
elastic properties of wheat straw, which make the particles rigid to compression pressure. The …
elastic properties of wheat straw, which make the particles rigid to compression pressure. The …
Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes
The epithelial-to-mesenchymal transition (EMT) produces cancer cells that are invasive,
migratory, and exhibit stem cell characteristics, hallmarks of cells that have the potential to …
migratory, and exhibit stem cell characteristics, hallmarks of cells that have the potential to …